The role of type I interferons in TLR responses
Abstract
Recent advances in unravelling the complexities of the signalling pathways that constitute innate immunity have highlighted type I interferon as a key component in the response to infection. Here we focus on the emerging field of pattern-recognition receptor signalling, specifically Toll-like receptors and retinoic acid inducible gene-like helicases, from the perspective of this 50-year-old cytokine. The type I interferon gene family encompasses more than 20 subtypes, whose nature and properties have been extensively studied during its relatively long history. In this review we update and integrate available data on the mechanics of activation of the interferon genes and the role of this cytokine family in the innate immune response.
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TET2 regulates primarily genes involved in the innate immune response and more specifically genes related to the TLR induced-Type I IFN response.
“We found that TET2 regulates primarily genes involved in the innate immune response and more specifically genes related to the TLR induced-Type I IFN response (e.g., Stat1, Stat3, Irf1, Irf7 ) (Noppert et al., 2007)(Luu et al., 2014).”
From TET2 Regulates the Neuroinflammatory Response in Microglia (2019) · cites this paper as Noppert et al., 2007
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References 160 · Cited by 135
- Authors
- Noppert, S. J., Fitzgerald, K. A., & Hertzog, P. J.
- Affiliations
- Monash University (AU)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Hertzog, Paul J
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2007-07-31
- Volume
- 85
- Issue
- 6
- Pages
- 446-457
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W2059355181
- Cited by
- 135
- References
- 160
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 10 · 2016: 7 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 15
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- type I interferon, Toll-like receptors, pattern recognition receptors, innate immunity, antiviral defense
- MeSH terms
- Animals, Base Sequence, Communicable Diseases, Humans, Interferon Type I, Molecular Sequence Data, Transcription, Genetic, Signal Transduction, Receptors, Interferon, Toll-Like Receptors
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