MRI reveals that early changes in cerebral blood volume precede blood–brain barrier breakdown and overt pathology in MS-like lesions in rat brain
Open accessAbstract
Magnetic resonance imaging (MRI) is an established clinical tool for diagnosing multiple sclerosis (MS), the archetypal central nervous system neuroinflammatory disease. In this study, we have used a model of delayed-type hypersensitivity in the rat brain, which bears many of the hallmarks of an MS lesion, to investigate the development of MRI-detectable changes before the appearance of conventional indices of lesion development. In addition, we have correlated the MRI-detectable changes with the developing histopathology. Significant increases in regional cerebral blood volume (rCBV) preceded overt changes in blood-brain barrier (BBB) permeability, T2 relaxation and the diffusion properties of tissue water. Thus, changes in rCBV might be a more sensitive indicator of lesion onset than the conventional indices used clinically in MS patients, such as contrast enhancement. In addition, we show that BBB breakdown, and consequent edema formation, are more closely correlated with astrogliosis than any other histopathologic changes, while regions of T1 and T2 hypointensity appear to reflect hypercellularity.
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Reduced diffusivity has also been observed in EAE, particularly in the lesion center with abundant astrocytosis and densely packed macrophages.
“However, reduced diffusivity has also been observed in EAE, particularly in the lesion center with abundant astrocytosis and densely packed macrophages (Broom et al., 2005).”
From Diffusion tensor imaging of post mortem multiple sclerosis brain (2007) · cites this paper as Broom et al., 2005
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Filippi, M., Rocca, M. A., Martino, G., Horsfield, M. A., & Comi, G. (1998) · Annals of Neurology · doi:10.1002/ana.410430616 · Cited by 395 · see citing works
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Diffusion tensor imaging of post mortem multiple sclerosis brain
Schmierer, K., Wheeler-Kingshott, C. A. M., Boulby, P. A., Scaravilli, F., Altmann, D. R., Barker, G. J., Tofts, P. S., & Miller, D. H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.010 · Cited by 395 · see citing works
Morgan, L., Shah, B., Rivers, L. E., Barden, L., Groom, A. J., Chung, R., Higazi, D., Desmond, H., Smith, T., & Staddon, J. M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.051 · Cited by 118 · see citing works
ABCD1 dysfunction alters white matter microvascular perfusion
Lauer, A., Da, X., Hansen, M. B., Boulouis, G., Ou, Y., Cai, X., Liberato Celso Pedrotti, A., Kalpathy-Cramer, J., Caruso, P., Hayden, D. L., et al. (2017) · Brain · doi:10.1093/brain/awx262 · Cited by 48 · see citing works
- Authors
- Broom, K. A., Anthony, D. C., Blamire, A. M., Waters, S., Styles, P., Perry, V. H., & Sibson, N. R.
- Affiliations
- University of Oxford (GB)
- University of Southampton (GB)
- Corresponding author
- Broom, Kerry A
- ORCID
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2005-02
- Volume
- 25
- Issue
- 2
- Pages
- 204-216
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2014072848
- Cited by
- 47
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 4 · 2013: 6 · 2012: 1
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- multiple sclerosis, cerebral blood volume, blood-brain barrier disruption, T2 relaxation, diffusion properties, edema, astrocyte activation, hypercellularity, contrast enhancement, rat brain
- MeSH terms
- Animals, Blood Volume, Blood-Brain Barrier, Brain, Disease Models, Animal, Hypersensitivity, Delayed, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Multiple Sclerosis, Permeability, Radiographic Image Enhancement, Rats, Inbred Lew, Rats
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