Oxygen-Dependent differentiation of human keratinocytes
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The 34 genes in the hypoxia gene module have been experimentally shown to be upregulated in response to hypoxia and/or possess a hypoxia response element in the promoter region.
“a manually curated list of 34 genes that have been experimentally shown to be upregulated in response to hypoxia and/or possess a hypoxia response element in the promoter region59–62”
From Single-cell transcriptomics of human-skin-equivalent organoids (2023) · cites this paper as [62]
The Results (page unavailable in our copy) experimentally show higher VEGF and COX-2 mRNA expression in human keratinocytes at lower oxygen levels. The paper does not establish that all 34 genes in the citing authors’ module meet the stated criteria, nor does it identify hypoxia response elements in their promoters. (LLM, conf=0.87)
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Research works printed but not linked: 3
- Howell-Jones RS, Wilson MJ, Hill KE, Howard AJ, Price PE, Thomas DW (2005) A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. J Antimicrob Chemother 55:143-9
- Roeckl-Wiedmann I, Bennett M, Kranke P (2005) Systematic review of hyperbaric oxygen in the management of chronic wounds. Br J Surg 92:24-32
- Widmaier EP, Raff H, Strang KT (2006) Vander's human physiology: The mechanisms of body function. McGraw-Hill: New York, 496-499
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Single-cell transcriptomics of human-skin-equivalent organoids
Stabell, A. R., Lee, G. E., Jia, Y., Wong, K. N., Wang, S., Ling, J., Nguyen, S. D., Sen, G. L., Nie, Q., & Atwood, S. X. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112511 · Cited by 30 · see citing works
- Authors
- Ngo, M. A., Sinitsyna, N. N., Qin, Q., & Rice, R. H.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Rice, Robert H.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 127
- Issue
- 2
- Pages
- 354-361
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2030168064
- Cited by
- 54
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 7 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p30es005707-15)
- U.S. Public Health Service
- National Institute of Environmental Health Sciences (P42-ES-04699, P42ES004699, P 30 ES05707)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR27130, R01AR027130)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxygen, keratinocyte differentiation, epidermis, hypoxia, keratinocyte growth, squamous differentiation, clonogenicity, vascular endothelial growth factor, cyclooxygenase-2, glutathione, AP-1 transcription factor, involucrin, epidermal stratification
- MeSH terms
- Cell Differentiation, Cell Division, Cell Nucleus, Cells, Cultured, Dose-Response Relationship, Drug, Electrophoresis, Glutathione, Humans, Osmolar Concentration, Oxygen, Keratinocytes, Proto-Oncogene Proteins c-jun, Proto-Oncogene Proteins c-fos, Vascular Endothelial Growth Factor A, Cyclooxygenase 2
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