Androgen receptor co-activator Hic-5/ARA55 as a molecular regulator of androgen sensitivity in dermal papilla cells of human hair follicles
Open accessAbstract
Androgen site-specifically affects human hair growth after puberty through androgen receptors in the dermal papilla, which transactivate target genes acting in conjunction with co-activators. To examine the regulation of androgen sensitivity in hair follicles, we focused on androgen receptor co-activator Hic-5/ARA55. Its interaction with transfected androgen receptor in beard dermal papilla cells was confirmed with mammalian two-hybrid assays. The semiquantitative reverse transcriptase-polymerase chain reaction showed that Hic-5/ARA55 mRNA expression was high in dermal papilla cells from the beard and bald frontal scalp but low in cells from the occipital scalp. To determine whether Hic-5/ARA55 mRNA level correlates with its endogenous activity, we studied the effect of dominant negative Hic-5/ARA55 on transfected androgen receptor transactivation induced by R1881 using mouse mammary tumor virus-luciferase assays. We found that it suppressed the transactivation by 64.5 and 71.4% in dermal papilla cells from the beard and bald frontal scalp, respectively, whereas it showed no significant effect in cells from the occipital scalp. Our findings suggest that Hic-5/ARA55 is a molecular regulator for androgen sensitivity in human hair follicles.
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References 26 · Cited by 39
- Authors
- Inui, S., Fukuzato, Y., Nakajima, T., Kurata, S., & Itami, S.
- Affiliations
- The University of Osaka (JP)
- Corresponding author
- Itami, Satoshi
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 127
- Issue
- 10
- Pages
- 2302-2306
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1973783550
- Cited by
- 39
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgen sensitivity, dermal papilla cells, hair follicle, androgen receptor transactivation, R1881, androgenetic alopecia, scalp hair follicles, gene expression
- MeSH terms
- Adolescent, Adult, Androgens, Cells, Cultured, Face, Hair, Humans, Male, Mammary Tumor Virus, Mouse, Receptors, Androgen, RNA, Messenger, Scalp, Transfection, Transcriptional Activation, Hair Follicle, Intracellular Signaling Peptides and Proteins, LIM Domain Proteins
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