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Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation
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In the citing paper
“Several reports point to hyperactivation of PI3K signaling in AML, and activated AKT is commonly associated with poor overall survival of patients with AML as well as with a less complete response (CR) rate to chemotherapy (18–23).”
From Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway (2023) · cites this paper as [19]
In the citing paper
“Several reports point to hyperactivation of PI3K signaling in AML, and activated AKT is commonly associated with poor overall survival of patients with AML as well as with a less complete response (CR) rate to chemotherapy (18–23).”
From Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway (2023) · cites this paper as [19]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 8
- Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA . JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 2004; 18: 189–218. · DOI
- Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M . Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 2003; 102: 972–980. · DOI · Paper page
- Min YH, Eom JI, Cheong JW, Maeng HO, Kim JY, Jeung HK et al. Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable. Leukemia 2003; 17: 995–997. · DOI · Paper page
- Woods Ignatoski KM, Livant DL, Markwart S, Grewal NK, Ethier SP . The role of phosphatidylinositol 3'-kinase and its downstream signals in erbB-2-mediated transformation. Mol Cancer Res 2003; 1: 551–560.
- Kubota Y, Tanaka T, Kitanaka A, Ohnishi H, Okutani Y, Waki M et al. Src transduces erythropoietin-induced differentiation signals through phosphatidylinositol 3-kinase. EMBO J 2001; 20: 5666–5677. · DOI
- Ohnishi H, Ledbetter JA, Kanner SB, Linsley PS, Tanaka T, Geller AM et al. CD28 cross-linking augments TCR-mediated signals and costimulates superantigen responses. J Immunol 1995; 154: 3180–3193. · DOI
- Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 1998; 12: 1333–1337. · DOI
- Lee Jr JT, McCubrey JA . The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 2002; 16: 486–507. · DOI
Cited by
Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway
Palam, L. R., Ramdas, B., Pickerell, K., Pasupuleti, S. K., Kanumuri, R., Cesarano, A., Szymanski, M., Selman, B., Dave, U. P., Sandusky, G., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.163864 · Cited by 13
Metadata
- Authors
- Kubota, Y., Ohnishi, H., Kitanaka, A., Ishida, T., & Tanaka, T.
- Venue
- Leukemia
- Published
- 2004-06-03
- Volume
- 18
- Issue
- 8
- Pages
- 1438-1440
- ISSN
- 0887-6924
- 1476-5551
- Cited by
- 60
- References
- 0
- Language
- en
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation. https://app.cochat.ai/papers/10.1038/sj.leu.2403402
- The paper
- Kubota, Y., Ohnishi, H., Kitanaka, A., Ishida, T., & Tanaka, T. (2004). Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation. Leukemia. https://doi.org/10.1038/sj.leu.2403402
