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Cited by 40

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells

Yao, C J, Works, K, Romagnoli, P A, Austin, G E·2005·Leukemia
DOI 10.1038/sj.leu.2403918
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Abstract

HMG-box containing protein 1 (HBP1) is a member of the high mobility group (HMG) of chromosomal proteins. Since HBP1 exhibits tumor-suppressor activity in nonmyeloid tissues, we examined the effects of ectopic overexpression of HBP1 upon the growth and differentiation of myeloid cells. We prepared transient and stable transfectants of the myeloblast cell line K562, which overexpress HBP1 mRNA and protein. HBP1 transfectants displayed slower growth in cell culture and reduced colony formation in soft agar, retardation of S-phase progression, reduced expression of cyclin D1 and D3 mRNAs and increased expression of p21 mRNA. HBP1 transfectants also underwent increased apoptosis, as demonstrated by morphology and binding of Annexin V. Fas ligand mRNA levels were increased in HBP1 transfectants, suggesting involvement of the Fas/Fas ligand pathway. HBP1 overexpression enhanced differentiation of K562 cells towards erythroid and megakaryocyte lineages, as evidenced by increased hemoglobin and CD41a expression. Overexpression of HBP1 modulated mRNA levels for myeloid-specific transcription factors C/EBPalpha, c-Myb, c-Myc, and JunB, as well as lineage-specific transcription factors PU.1, GATA-1, and RUNX1. These findings suggest that in myeloid cells HBP1 may serve as a tumor suppressor and a general differentiation inducer and may synergize with chemical differentiating agents to enhance lineage-specific differentiation.

Overview

Integrity signals

Registry

Crossref · 10.1038/sj.leu.2403918

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

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Verification

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Citations

Cites

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Metadata

Authors
Yao, C. J., Works, K., Romagnoli, P. A., & Austin, G. E.
Venue
Leukemia
Publisher
Springer Science and Business Media LLC
Published
2005-09-22
Volume
19
Issue
11
Pages
1958-1968
ISSN
  • 0887-6924
  • 1476-5551
DOI
10.1038/sj.leu.2403918
Cited by
40
References
35
Language
en
Licence

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.