The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Pathophysiology of Preeclampsia: Linking Placental Ischemia/Hypoxia with Microvascular Dysfunction
Abstract
Studies during the past decade have provided a better understanding of the potential mechanisms responsible for the pathogenesis of preeclampsia. The initiating event in preeclampsia has been postulated to be reduced uteroplacental perfusion as a result of abnormal cytotrophoblast invasion of spiral arterioles. Placental ischemia/hypoxia is thought to lead to widespread activation/dysfunction of the maternal vascular endothelium which results in enhanced formation of endothelin, thromboxane, and superoxide, increased vascular sensitivity to angiotensin II, and decreased formation of vasodilators such as nitric oxide and prostacyclin. These endothelial abnormalities, in turn, cause hypertension by impairing renal function and increasing total peripheral resistance. While recent studies support a role for cytokines and other factors such as lipid peroxides and reactive oxygen intermediates as potential mediators of endothelial dysfunction, finding the link between placental ischemia/hypoxia and maternal endothelial and vascular abnormalities remains an important area of investigation. The quantitative importance of the various endothelial and humoral factors in mediating the vasoconstriction and elevation in arterial pressure during preeclampsia has also not been completely elucidated.
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Cites
Wegmann, T. G., Lin, H., Guilbert, L., & Mosmann, T. R. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90235-d · Cited by 2,852
Preeclampsia: an endothelial cell disorder
Roberts, J. M., Taylor, R. N., Musci, T. J., Rodgers, G. M., Hubel, C. A., & McLaughlin, M. K. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90665-0 · Cited by 1,859
Cytokines and endothelial cell biology
Pober, J. S., & Cotran, R. S. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.427 · Cited by 1,242
Zhou, Y., Fisher, S. J., Janatpour, M., Genbacev, O., Dejana, E., Wheelock, M., & Damsky, C. H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119387 · Cited by 959
The role of the spiral arteries in the pathogenesis of pre-eclampsia.
Brosens, I. A., Robertson, W. B., & Dixon, H. G. (1970) · PubMed · Cited by 953
Regulation of Human Placental Development by Oxygen Tension
Genbacev, O., Zhou, Y., Ludlow, J. W., & Fisher, S. J. (1997) · Science · doi:10.1126/science.277.5332.1669 · Cited by 914
Synthesis of T helper 2-type cytokines at the maternal-fetal interface.
Lin, H., Mosmann, T. R., Guilbert, L., Tuntipopipat, S., & Wegmann, T. G. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.4562 · Cited by 899
Ion exchange resins in the treatment and prophylaxis of pre-eclampsia.
Brosens, I. A., Robertson, W. B., & Dixon, H. (1953) · PubMed · Cited by 702
Sladek, S. M., Magness, R. R., & Conrad, K. P. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.2.r441 · Cited by 673
Placental bed spiral arteries in the hypertensive disorders of pregnancy
PIJNENBORG, R., ANTHONY, J., DAVEY, D. A., REES, A., TILTMAN, A., VERCRUYSSE, L., & VAN ASSCHE, A. (1991) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb13450.x · Cited by 673
Cited by
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Chaiworapongsa, T., Romero, R., Kim, Y. M., Kim, G. J., Kim, M. R., Espinoza, J., Bujold, E., Gonçalves, L., Gomez, R., Edwin, S., et al. (2005) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050400028816 · Cited by 359
Recurrence of ischemic placental disease
Ananth, C. V., Peltier, M. R., Chavez, M. R., Kirby, R. S., Getahun, D., & Vintzileos, A. M. (2007) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000266983.77458.71 · Cited by 177
Recent Progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia
LaMarca, B. D., Gilbert, J., & Granger, J. P. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.108837 · Cited by 142
Self-citationBujold, E., Romero, R., Chaiworapongsa, T., KIM, Y. M., Kim, G. J., Kim, M. R., Espinoza, J., Gonçalves, L. F., Edwin, S., & Mazor, M. (2005) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050500202493 · Cited by 110
Metadata
- Authors
- GRANGER, J. P., ALEXANDER, B. T., LLINAS, M. T., BENNETT, W. A., & KHALIL, R. A.
- Venue
- Microcirculation
- Publisher
- Wiley
- Published
- 2002-06
- Volume
- 9
- Issue
- 3
- Pages
- 147-160
- ISSN
- 1073-9688 (ISSN-L)
- 1549-8719
- OpenAlex
- W2082059445
- Cited by
- 334
- References
- 72
- FWCI
- 17.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- GRANGER, J. P., ALEXANDER, B. T., LLINAS, M. T., BENNETT, W. A., & KHALIL, R. A. (2002). Pathophysiology of Preeclampsia: Linking Placental Ischemia/Hypoxia with Microvascular Dysfunction. Microcirculation. https://doi.org/10.1038/sj.mn.7800137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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