A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity
Abstract
Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. Genetic variation in the human TPH2 gene (hTPH2) has been associated with altered in vitro enzyme activity as well as increased risk for mood disorders. Here, we provide the first in vivo evidence that a relatively frequent regulatory variant (G(-844)T) of hTPH2 biases the reactivity of the amygdala, a neural structure critical in the generation and regulation of emotional behaviors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Polymorphisms of TPH2 have independent effects on amygdala activation.
“Polymorphisms of the TPH2 gene have been reported to have independent (Brown et al., 2005;Canli et al., 2005) and additive effects with the 5-HTTLPR genotype (Canli et al., 2008;Furmark et al., 2009) on amygdala activation.”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Brown et al., 2005
The citation lists haven’t been fetched yet
References 35 · Cited by 241
- Authors
- Brown, S. M., Peet, E., Manuck, S. B., Williamson, D. E., Dahl, R. E., Ferrell, R. E., & Hariri, A. R.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Hariri, A R
- Venue
- Molecular Psychiatry
- Published
- 2005-07-26
- Volume
- 10
- Issue
- 9
- Pages
- 884-888
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2103748523
- Cited by
- 241
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 9 · 2015: 15 · 2014: 5 · 2013: 14 · 2012: 24
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL065137, P01HL040962)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- tryptophan hydroxylase 2, TPH2 gene, regulatory variants, amygdala reactivity, serotonin synthesis, genetic variation, emotional behavior, mood disorders, gene expression regulation
- MeSH terms
- Amygdala, Brain, Emotions, Gene Frequency, Genotype, Humans, Magnetic Resonance Imaging, Oxygen, Tryptophan Hydroxylase, Genetic Variation, Sequence Deletion
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
