Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects
Abstract
The cholinergic neurotransmitter system has been proposed to be involved in the processing of probabilistic top-down information provided by endogenous cues in location-cueing paradigms. It has been shown that the behavioral and neural effects of a nicotinic cholinergic stimulation resemble the effects obtained by manipulating the validity of the spatial cues: enhancing cortical nicotine levels and decreasing cue validity both reduce the reaction time difference between invalidly and validly cued targets (ie, the 'validity effect') as well as neural activity related to attentional reorienting in parietal brain regions. In the present study, we investigated whether the behavioral and neural effects of nicotine in location-cueing paradigms are dependent upon different a priori cue validities. Twenty-four subjects were investigated in a double-blind placebo-controlled between-subject design with functional magnetic resonance imaging. Nicotine was administered to non-smoking volunteers via polacrilex gums (Nicorette, 2 mg) before performing a location-cueing paradigm with valid and invalid cues in the context of 90 and 60% cue validity in the MR scanner. Nicotine significantly reduced the validity effect in the 90% but not in the 60% cue validity condition. Fronto-parietal and cingulate regions showed stronger nicotinic reductions of reorienting-related neural activity in the high than in the low cue validity condition. Our data reveal an interaction effect between the pharmacological and cognitive modulation of attentional reorienting, which is evident at both a behavioral as well as the neuronal level.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Administration of nicotine to subjects undergoing fMRI scanning did not consistently produce significant effects on cognitive performance.
“Similar to the purely behavioral studies discussed above, administration of nicotine to subjects undergoing fMRI scanning did not consistently produce significant effects on cognitive performance (Giessing et al, 2006; Thiel and Fink, 2008; Vossel et al, 2008).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Vossel et al, 2008
Nicotine enhanced neuronal activity in prefrontal cingulate and parietal regions specifically in trials requiring cue detection and attentional re-orienting in subjects performing a cued target detection task.
“However, consistent with the conclusions derived from experiments in rodents, nicotine enhanced neuronal activity in prefrontal cingulate and parietal regions specifically in trials requiring cue detection and attentional re-orienting in subjects performing a cued target detection task (Giessing et al, 2006; Vossel et al, 2008).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Vossel et al, 2008
The citation lists haven’t been fetched yet
References 39 · Cited by 81
- Authors
- Vossel, S., Thiel, C. M., & Fink, G. R.
- Affiliations
- Forschungszentrum Jülich (DE)
- Carl von Ossietzky Universität Oldenburg (DE)
- Corresponding author
- Vossel, Simone
- Venue
- Neuropsychopharmacology
- Published
- 2007-06-06
- Volume
- 33
- Issue
- 4
- Pages
- 731-738
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2060820092
- Cited by
- 81
- References
- 39
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 11 · 2013: 10 · 2012: 3
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- nicotine, attentional reorienting, visuospatial attention, cue validity, validity effect, cholinergic system, nicotinic acetylcholine receptors, parietal cortex, cingulate cortex, frontoparietal cortex
- MeSH terms
- Adult, Analysis of Variance, Attention, Brain Mapping, Cues, Double-Blind Method, Eye Movements, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nicotine, Oxygen, Photic Stimulation, Reaction Time, Space Perception, Visual Cortex, Nicotinic Agonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
