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The TEL gene products: nuclear phosphoproteins with DNA binding properties
Abstract
The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA and the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first inframe ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events.
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“It also has the oligomerization domain (also called the pointed [PNT] domain, B domain, or HLH domain) in the N terminus that is conserved in several Ets members, but not in PU.1 (33, 39).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [39]
In the citing paper
“the TEL gene encodes at least two phosphoproteins, both isoforms being subject to common and distinct phosphorylation events (39).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [39]
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Items 101–109 of 109
Sinnett, D. (2016) · Cancer Science & Research Open Access · doi:10.15226/csroa.2016.00124 · Cited by 1
Mix and Match Gene Fusions with TEL and AMLl
Aloisi, A., Daniotti, M., Cazzaniga, G., et al. (2003) · Hämatologie und Bluttransfusion · doi:10.1007/978-3-642-59358-1_9
Hasse, K. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-17508
Genetic and BiologicalDiversity in TEL-AML1 Positive ALL
Stams, W. A. G. (2005) · RePub (Erasmus University Rotterdam)
Molecular characterization of pediatric spindle cell tumors
Knezevich, S. R. (2009) · Library and Archives Canada (Government of Canada) · doi:10.14288/1.0089630
TEL/ABL PATHOGENESIS: CHRONIC MYELOGENOUS LEUKEMIA AND SMALL BOWEL SYNDROME
Verter, E. E. (2009) · Brandeis Institutional Repository
Kern, W., Haferlach, T., & Hiddemann, W. (2004) · Springer eBooks · doi:10.1007/978-3-662-06670-6_75
Vrobelova, K., Jakl, L., Škorvaga, M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-88204-z
Metadata
- Authors
- Poirel, H., Oury, C., Carron, C., Duprez, E., Laabi, Y., Tsapis, A., Romana, S. P., Mauchauffe, M., Le Coniat, M., Berger, R., Ghysdael, J., & Bernard, O. A.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Venue
- Oncogene
- Published
- 1997-01-23
- Volume
- 14
- Issue
- 3
- Pages
- 349-357
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2002377159
- Cited by
- 106
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Funders
- Ligue Contre le Cancer
- Topics
- Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- ETS transcription factors, nuclear phosphoprotein, 21)(p13, childhood acute lymphoblastic leukemia, alternative translation initiation, hematologic malignancies
- MeSH terms
- ETS Translocation Variant 6 Protein, Animals, Base Sequence, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 21, Cloning, Molecular, DNA, DNA-Binding Proteins, Humans, Molecular Sequence Data, Nuclear Proteins, Phosphoproteins, Phosphorylation, Repressor Proteins, RNA, Messenger, Transcription Factors, Translocation, Genetic, Tumor Cells, Cultured, Blotting, Western, Leukemia, B-Cell, In Situ Hybridization, Fluorescence, DNA, Complementary, COS Cells, Proto-Oncogene Proteins c-ets, Mice
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