The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis
Abstract
Mitochondrial membrane permeabilization is a critical event in the process leading to physiological or chemotherapy-induced apoptosis. This permeabilization event is at least in part under the control of the permeability transition pore complex (PTPC), which interacts with oncoproteins from the Bcl-2 family as well as with tumor suppressor proteins from the Bax family, which inhibit or facilitate membrane permeabilization, respectively. Here we show that thiol crosslinking agents including diazenedicarboxylic acid bis 5N, N-dimethylamide (diamide), dithiodipyridine (DTDP), or bis-maleimido-hexane (BMH) can act on the adenine nucleotide translocator (ANT), one of the proteins within the PTPC. ANT alone reconstituted into artificial lipid bilayers suffices to confer a membrane permeabilization response to thiol crosslinking agents. Diamide, DTDP, and BMH but not tert-butylhydroperoxide or arsenite cause the oxidation of a critical cysteine residue (Cys 56) of ANT. Thiol modification within ANT is observed in intact cells, isolated mitochondria, and purified ANT. Recombinant Bcl-2 fails to prevent thiol modification of ANT. Concomitantly, a series of different thiol crosslinking agents (diamide, DTDP, and BMH, phenylarsine oxide) but not tert-butylhydroperoxide or arsenite induce mitochondrial membrane permeabilization and cell death irrespective of the expression level of Bcl-2. These data indicate that thiol crosslinkers cause a covalent modification of ANT which, beyond any control by Bcl-2, leads to mitochondrial membrane permeabilization and cell death.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“it is known that modification of redox-sensitive thiols in this mitochondrial protein regulates the formation of the mitochondrial permeability transition (MPT) pore and cell death (101).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [101]
In the citing paper
“In contrast, the redox-sensitive thiols of ANT have been well studied as targets for modification by nitric oxide, peroxynitrite, thiol crosslinkers, and other thiol-reactive reagents (101, 435).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [101]
Citations
Cites
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Yang, J., Liu, X., Bhalla, K. N., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X. (1997) · Science · doi:10.1126/science.275.5303.1129 · Cited by 4,913
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
Kluck, R. M., Bossy‐Wetzel, E., Green, D. R., & Newmeyer, D. D. (1997) · Science · doi:10.1126/science.275.5303.1132 · Cited by 4,715
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060
Self-citationBcl-2 functions in an antioxidant pathway to prevent apoptosis
Hockenbery, D. M., Oltvai, Z. N., Yin, X., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,402
Shimizu, S., Narita, M., Tsujimoto, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/20959 · Cited by 2,178
THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS
Kroemer, G., Dallaporta, B., & Resche-Rigon, M. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.619 · Cited by 1,975
Self-citationBcl-2 inhibition of neural death: decreased generation of reactive oxygen species
Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., Gralla, E. B., Valentine, J. S., Örd, T., & Bredesen, D. E. (1993) · Science · doi:10.1126/science.8235659 · Cited by 1,671
Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignotte, B., & Kroemer, G. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.2.367 · Cited by 1,567
Self-citation
Research works printed but not linked: 2
- Brenner C, Cadiou H, Vieira HLA, Zamzami N, Marzo I, Xie Z, Leber B, Andrews D, Duclohier H, Reed JC and Kroemer G . 1999 Oncogene, in press.
- Susin SA, Larochette N, Geuskens M and Kroemer G . 1999a Meth Enzymol, in press.
Cited by
Sorted by citations
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
Self-citationTargeting mitochondria for cancer therapy
Fulda, S., Galluzzi, L., & Kroemer, G. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3137 · Cited by 1,678
Self-citationThe mitochondrion in apoptosis: how Pandora's box opens
Zamzami, N., & Kroemer, G. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35048073 · Cited by 1,055
Self-citationReactive Oxygen Species: A Breath of Life or Death?
Fruehauf, J. P., & Meyskens, F. L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2082 · Cited by 921
Mitochondrial permeability transition and oxidative stress
Kowaltowski, A. J., Castilho, R. F., & Vercesi, A. E. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02316-x · Cited by 832
Zhao, K., Zhao, G.-M., Wu, D., Soong, Y., Birk, A. V., Schiller, P. W., & Szeto, H. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402999200 · Cited by 782
Imai, H., & Nakagawa, Y. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01197-8 · Cited by 776
Azad, M. B., Chen, Y., & Gibson, S. B. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2270 · Cited by 764
Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
Buytaert, E., Dewaele, M., & Agostinis, P. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.07.001 · Cited by 768
The permeability transition pore complex: another view
Halestrap, A. P., McStay, G. P., & Clarke, S. J. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01375-5 · Cited by 709
Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy
Yang, Y., Karakhanova, S., Hartwig, W., D’Haese, J. G., Philippov, P. P., Werner, J., & Bazhin, A. V. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25349 · Cited by 687
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging
Marchi, S., Giorgi, C., Suski, J. M., Agnoletto, C., Bononi, A., Bonora, M., Marchi, E. D., Missiroli, S., Patergnani, S., Poletti, F., et al. (2011) · Journal of Signal Transduction · doi:10.1155/2012/329635 · Cited by 658
Deniaud, A., Sharaf el dein, O., Maillier, E., Poncet, D., Kroemer, G., Lemaire, C., & Brenner, C. (2008) · Oncogene · doi:10.1038/sj.onc.1210638 · Cited by 586
Self-citationRedox regulation of mitochondrial function
Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588
Ueda, S., Masutani, H., Nakamura, H., Tanaka, T., Ueno, M., & Yodoi, J. (2002) · Antioxidants and Redox Signaling · doi:10.1089/15230860260196209 · Cited by 552
Mitochondrial Control of Cellular Life, Stress, and Death
Galluzzi, L., Kepp, O., Trojel‐Hansen, C., & Kroemer, G. (2012) · Circulation Research · doi:10.1161/circresaha.112.268946 · Cited by 568
Self-citationMitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling
Cox, A. G., Winterbourn, C. C., & Hampton, M. B. (2009) · Biochemical Journal · doi:10.1042/bj20091541 · Cited by 550
Mitochondrion as a Novel Target of Anticancer Chemotherapy
Costantini, P. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.13.1042 · Cited by 530
Self-citationRecent advances in apoptosis, mitochondria and drug resistance in cancer cells
Indran, I. R., Tufo, G., Pervaiz, S., & Brenner, C. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.03.010 · Cited by 534
Self-citationLysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion
Boya, P., Andreau, K., Poncet, D., Zamzami, N., Perfettini, J.-L., Metivier, D., Ojcius, D. M., Jäättelä, M., & Kroemer, G. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021952 · Cited by 483
Self-citationZhang, S., Ong, C. N., & Shen, H. (2004) · Cancer Letters · doi:10.1016/j.canlet.2003.11.028 · Cited by 483
Chemotherapy: targeting the mitochondrial cell death pathway
Debatin, K., Poncet, D., & Kroemer, G. (2002) · Oncogene · doi:10.1038/sj.onc.1206039 · Cited by 399
Self-citationThe Mitochondrion in Cell Death Control: Certainties and Incognita
Loeffler, M. W., & Kroemer, G. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4833 · Cited by 393
Self-citationInteractions between mitochondrial reactive oxygen species and cellular glucose metabolism
Liemburg-Apers, D. C., Willems, P. H. G. M., Koopman, W. J. H., & Grefte, S. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1520-y · Cited by 412
Chang, T.-S., Cho, C.-S., Park, S., Yu, S., Kang, S. W., & Rhee, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407707200 · Cited by 388
Jan, G., Belzacq, A.-S., Haouzi, D., Rouault, A., Métivier, D., Kroemer, G., & Brenner, C. (2002) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400935 · Cited by 385
Self-citationMcSTAY, G. P., CLARKE, S. J., & HALESTRAP, A. P. (2002) · Biochemical Journal · doi:10.1042/bj20011672 · Cited by 367
Glutathione in liver diseases and hepatotoxicity
Yuan, L., & Kaplowitz, N. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.08.003 · Cited by 359
Reactive oxygen species and the mitochondrial signaling pathway of cell death.
Bras, M. L., Clément, M.-V., Pervaiz, S., & Brenner, C. (2005) · PubMed · doi:10.14670/hh-20.205 · Cited by 360
Self-citationMitochondria as therapeutic targets for cancer chemotherapy
Galluzzi, L., Larochette, N., Zamzami, N., & Kroemer, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209598 · Cited by 342
Self-citationBonora, M., Wieckowski, M. R., Chinopoulos, C., Kepp, O., Kroemer, G., Galluzzi, L., & Pinton, P. (2015) · Oncogene · doi:10.1038/onc.2014.96 · Cited by 330
Self-citationLeung, A. W. C., & Halestrap, A. P. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.009 · Cited by 323
Mitochondrial Channels: Ion Fluxes and More
Szabó, I., & Zoratti, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00021.2013 · Cited by 330
Signalling apoptosis: a radical approach
Carmody, R. J., & Cotter, T. G. (2001) · Redox Report · doi:10.1179/135100001101536085 · Cited by 308
Nanopreparations for organelle-specific delivery in cancer
Biswas, S., & Torchilin, V. P. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.004 · Cited by 298
Jacotot, E. D., Ferri, K. F., Hamel, C. E., Brenner, C., Druillennec, S., Hoebeke, J., Rustin, P., Métivier, D., Lenoir, C., Geuskens, M., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.509 · Cited by 277
Self-citationYang, Z., Schumaker, L. M., Egorin, M. J., Zuhowski, E. G., Guo, Z., & Cullen, K. J. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1037 · Cited by 270
Zhao, K., Luo, G., Giannelli, S., & Szeto, H. H. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.08.022 · Cited by 251
The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal
Vieira, H. L., Belzacq, A.-S., Haouzi, D., Bernassola, F., Cohen, I., Jacotot, E., Ferri, K. F., El Hamel, C., Bartle, L. M., Melino, G., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204575 · Cited by 244
Self-citationMitochondrial Medicine: Pharmacological targeting of mitochondria in disease
Armstrong, J. S. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707288 · Cited by 239
Oxidative damage to mitochondria and aging
Remmen, H. V. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00093-6 · Cited by 233
Mitochondria: a target for cancer therapy
Armstrong, J. S. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706556 · Cited by 233
Catalase Takes Part in Rat Liver Mitochondria Oxidative Stress Defense
Salvi, M., Battaglia, V., Brunati, A. M., La Rocca, N., Tibaldi, E., Pietrangeli, P., Marcocci, L., Mondovi, B., Rossi, C. A., & Toninello, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701589200 · Cited by 231
Arsenic trioxide, a therapeutic agent for APL
Zhang, T.-D., Chen, G., Wang, Z., Wang, Z., Chen, S., & Chen, Z. (2001) · Oncogene · doi:10.1038/sj.onc.1204762 · Cited by 231
Knockout mice heterozygous forSod2show alterations in cardiac mitochondrial function and apoptosis
Remmen, H. V., Williams, M. D., Guo, Z., Estlack, L. E., Yang, H. C., Carlson, E. J., Epstein, C. J., Huang, T., & Richardson, A. G. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.3.h1422 · Cited by 231
Vieira, H. L. A., Haouzi, D., Hamel, C. E., Jacotot, E. D., Belzacq, A.-S., Brenner, C., & Kroemer, G. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400778 · Cited by 232
Self-citationGarcía‐Ruiz, C., Colell, A., Marı́, M., Morales, A., Calvo, M., Enrich, C., & Fernández-Checa, J. C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16010 · Cited by 228
Odin, J. A., Huebert, R. C., Casciola-Rosen, L., LaRusso, N. F., & Rosen, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200110716 · Cited by 220
The permeability transition pore complex in cancer cell death
Brenner, C., & Grimm, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209609 · Cited by 232
Self-citationArmstrong, J. S., & Jones, D. P. (2002) · The FASEB Journal · doi:10.1096/fj.02-0097fje · Cited by 221
Neuronal Apoptosis in Neurodegeneration
Okouchi, M., Ekshyyan, O. Y., Maracine, M., & Aw, T. Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1511 · Cited by 222
DNA strand breaks and apoptosis induced by oxaliplatin in cancer cells
Faivre, S. J., Chan, D., Salinas, R., Woynarowska, B., & WOYNAROWSKI, J. M. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00260-0 · Cited by 211
Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases
Martin, L. J. (2010) · Pharmaceuticals · doi:10.3390/ph3040839 · Cited by 213
Oxygen free radicals and redox biology of organelles
Moldovan, L., & Moldovan, N. I. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0676-y · Cited by 213
Ketone bodies are protective against oxidative stress in neocortical neurons
Kim, D. Y., Davis, L. M., Sullivan, P. G., Maalouf, M., Simeone, T. A., van Brederode, J. F. M., & Rho, J. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04483.x · Cited by 207
Mitochondria as a critical target of the chemotheraputic agent cisplatin in head and neck cancer
Cullen, K. J., Yang, Z., Schumaker, L. M., & Guo, Z. (2007) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-006-9059-5 · Cited by 197
Belzacq, A.-S., Hamel, C. E., Vieira, H. L. A., Cohen, I., Haouzi, D., Métivier, D., Marchetti, P., Brenner, C., & Kroemer, G. (2001) · Oncogene · doi:10.1038/sj.onc.1204953 · Cited by 191
Self-citationPrinciples in Redox Signaling: From Chemistry to Functional Significance
Bindoli, A., & Rigobello, M. P. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4655 · Cited by 194
Apoptotic effect of eugenol in human colon cancer cell lines
Jaganathan, S. K., Mazumdar, A., Mondhe, D. M., & Mandal, M. (2010) · Cell Biology International · doi:10.1042/cbi20100118 · Cited by 189
Redox active calcium ion channels and cell death
Waring, P. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.08.001 · Cited by 187
Martin, L. J., Gertz, B., Pan, Y. H., Price, A. C., Molkentin, J. D., & Chang, Q. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.02.015 · Cited by 186
Bid acts on the permeability transition pore complex to induce apoptosis
Zamzami, N., Hamel, C. E., Maisse, C., Brenner, C., Muñoz-Pinedo, C., Belzacq, A.-S., Costantini, P., Vieira, H., Loeffler, M., Molle, G., et al. (2000) · Oncogene · doi:10.1038/sj.onc.1204030 · Cited by 178
Self-citationPhysiological Roles of the Permeability Transition Pore
Brenner, C., & Moulin, M. (2012) · Circulation Research · doi:10.1161/circresaha.112.265942 · Cited by 186
Self-citationDimmeler, S., & Zeiher, A. M. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00105-1 · Cited by 178
Disruption of mitochondrial redox circuitry in oxidative stress
Jones, D. P. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.07.008 · Cited by 176
Brar, S. S., Grigg, C., Wilson, K. S., Holder, W. D., Dréau, D., Austin, C. E., Foster, M., Ghio, A. J., Whorton, A. R., Stowell, G. W., et al. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.1049.3.9 · Cited by 172
Burwell, L. S., & Brookes, P. S. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1845 · Cited by 177
Lluis, J. M., Colell, A., García‐Ruiz, C., Kaplowitz, N., & Fernández-Checa, J. C. (2003) · Gastroenterology · doi:10.1053/gast.2003.50089 · Cited by 172
The Role of Reactive Oxygen Species in the Life Cycle of the Mitochondrion
Venditti, P., & Meo, S. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062173 · Cited by 176
Programmed Death Phenomena: From Organelle to Organism
Skulachev, V. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02095.x · Cited by 171
Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1
Silva, A. P. P. D., El‐Bacha, T., Kyaw, N., dos Santos, R. S., da‐Silva, W. S., Almeida, F. C. L., Poian, A. T. D., & Galina, A. (2008) · Biochemical Journal · doi:10.1042/bj20080805 · Cited by 174
Bcl-2 and Bax modulate adenine nucleotide translocase activity.
Belzacq, A.-S., Vieira, H. L. A., Verrier, F., Vandecasteele, G., Cohen, I., Prévost, M., Larquet, É., Pariselli, F., Petit, P. X., Kahn, A., et al. (2003) · PubMed · Cited by 167
Self-citationBiology of Mitochondria in Neurodegenerative Diseases
Martin, L. J. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385883-2.00005-9 · Cited by 164
Gerasimenko, J. V., Gerasimenko, O. V., Palejwala, A. A., Tepikin, A. V., Petersen, O. H., & Watson, A. J. M. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.3.485 · Cited by 161
Anderson, E. J., Rodríguez, E., Anderson, C. A., Thayne, K. A., Chitwood, W. R., & Kypson, A. P. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00932.2010 · Cited by 165
Chen, Y., Cai, J., Murphy, T. J., & Jones, D. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202026200 · Cited by 160
Mitochondria and aging: A role for the mitochondrial transition pore?
Panel, M., Ghaleh, B., & Morin, D. (2018) · Aging Cell · doi:10.1111/acel.12793 · Cited by 152
Apoptosis and necrosis in health and disease: Role of mitochondria
Nieminen, A. (2003) · International review of cytology · doi:10.1016/s0074-7696(05)24002-0 · Cited by 147
Disulfiram induces apoptosis in human melanoma cells: a redox-related process.
Cen, D., Gonzalez, R. I., Buckmeier, J. A., Kahlon, R. S., Tohidian, N. B., & Meyskens, F. L. (2002) · PubMed · Cited by 145
Local Melatoninergic System as the Protector of Skin Integrity
Slominski, A. T., Kleszczyński, K., Semak, I. V., Janjetović, Z., Zmijewski, M. A., Kim, T., Slominski, R. M., Reiter, R. J., & Fischer, T. W. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151017705 · Cited by 148
Mitochondriotoxic compounds for cancer therapy
Fantin, V. R., & Leder, P. (2006) · Oncogene · doi:10.1038/sj.onc.1209599 · Cited by 145
3-bromopyruvate: Targets and outcomes
Shoshan, M. C. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9419-2 · Cited by 144
Li, M., Xia, T., Jiang, C.-S., Li, L.-J., Fu, J.-L., & Zhou, Z.-C. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00327-5 · Cited by 140
Mitochondrial permeability transition in apoptosis and necrosis
Zamzami, N., Larochette, N., & Kroemer, G. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401682 · Cited by 137
Self-citationThe mitochondrial permeability transition: Recent progress and open questions
Bernardi, P., Carraro, M., & Lippe, G. (2021) · FEBS Journal · doi:10.1111/febs.16254 · Cited by 150
The programmed death phenomena, aging, and the Samurai law of biology
Skulachev, V. P. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00109-7 · Cited by 134
Queiroga, C. S. F., Almeida, A. S., Martel, C., Brenner, C., Alves, P. M., & Vieira, H. L. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.065052 · Cited by 140
Self-citationHansen, J. M., Zhang, H., & Jones, D. P. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj175 · Cited by 131
Agostinelli, E., Arancia, G., Vedova, L. D., Belli, F., Marra, M., Salvi, M., & Toninello, A. (2004) · Amino Acids · doi:10.1007/s00726-004-0114-4 · Cited by 130
Boscolo, A., Milanović, D., Starr, J. A., Sanchez, V., Oklopcic, A., Moy, L., Ori, C., Erişir, A., & Jevtović‐Todorović, V. (2013) · Anesthesiology · doi:10.1097/aln.0b013e318289bc9b · Cited by 128
Precise Subcellular Organelle Targeting for Boosting Endogenous‐Stimuli‐Mediated Tumor Therapy
Zhen, W., An, S., Wang, S., Hu, W., Li, Y., Jiang, X., & Li, J. (2021) · Advanced Materials · doi:10.1002/adma.202101572 · Cited by 127
Oxygen toxicity: cellular mechanisms in normobaric hyperoxia
Alva, R., Mirza, M., Baiton, A., Lazuran, L., Samokysh, L., Bobinski, A. R., Cowan, C., Jaimon, A., Obioru, D., Makhoul, T. A., et al. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09773-7 · Cited by 141
The Modes of Cell Death Induced by PDT: An Overview
Plaetzer, K., Kiesslich, T., Verwanger, T., & Krammer, B. E. (2003) · Medical Laser Application · doi:10.1078/1615-1615-00082 · Cited by 125
Siegmund, S., Qian, T., Minicis, S. D., Harvey-White, J. D., Kunos, G., Vinod, K. Y., Hungund, B. L., & Schwabe, R. F. (2007) · The FASEB Journal · doi:10.1096/fj.06-7717com · Cited by 126
Apoptosis Following Photodynamic Tumor Therapy: Induction, Mechanisms and Detection
Plaetzer, K., Kiesslich, T., Oberdanner, C. B., & Krammer, B. E. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053507648 · Cited by 126
Gottlieb, R. A. (2001) · Neurosignals · doi:10.1159/000046884 · Cited by 118
Redox regulation and signaling lipids in mitochondrial apoptosis.
Fernández-Checa, J. (2003) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/s0006-291x(03)00619-3 · Cited by 120
Targeting mitochondria for cancer therapy
Hockenbery, D. M. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20552 · Cited by 124
The adenine nucleotide translocator in apoptosis
Belzacq, A.-S., Vieira, H. L. A., Kroemer, G., & Brenner, C. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01366-4 · Cited by 118
Self-citationKorotkov, S. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914459 · Cited by 126
Metadata
- Authors
- Costantini, P., Belzacq, A.-S., Vieira, H. L., Larochette, N., de Pablo, M. A., Zamzami, N., Susin, S. A., Brenner, C., & Kroemer, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Université de Technologie de Compiègne (FR)
- Venue
- Oncogene
- Published
- 2000-01-13
- Volume
- 19
- Issue
- 2
- Pages
- 307-314
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2053090763
- Cited by
- 284
- References
- 42
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 8 · 2017: 2 · 2016: 6 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 11
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- adenine nucleotide translocase, mitochondrial permeability transition pore, mitochondrial membrane permeabilization, apoptosis, cysteine oxidation, Bcl-2, Bax, mitochondrial permeability transition, covalent modification, diamide, phenylarsine oxide, tert-butyl hydroperoxide, arsenite
- MeSH terms
- Mitochondrial ADP, ATP Translocases, Animals, Cell Line, Cross-Linking Reagents, Humans, Hybridomas, Intracellular Membranes, Oxidation-Reduction, Permeability, Sulfhydryl Compounds, Rats, Wistar, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Macromolecular Substances, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
