STAT signaling in head and neck cancer
Abstract
The upper aerodigestive tract is predisposed to the formation of multiple primary tumors due to field cancerization. TGF-alpha/EGFR autocrine signaling appears to play an important role in squamous cell carcinoma of the head and neck (SCCHN) and upregulation of TGF-alpha and EGFR is an early event in SCCHN carcinogenesis. STAT proteins, including Stat3, are activated by TGF-alpha and EGFR and strategies that downmodulate TGF-alpha or EGFR inhibit SCCHN cell proliferation and abrogate Stat3 activation. Targeting Stat3 leads to SCCHN growth inhibition, increases apoptosis and a downmodulation of Bcl-xL expression in head and neck tumors. These studies support the role of Stat3 as an oncogene, which is activated early in SCCHN carcinogenesis, and efforts to understand EGFR-mediated Stat3 signaling could facilitate novel strategies that will interfere with this growth promoting pathway. Oncogene (2000).
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Aberrant STAT3 activation is an important early event during the development and progression of HNSCC and CRC.
“Aberrant STAT3 activation represents an important early event during the development and progression of HNSCC and CRC (4, 8)”
From Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer (2022) · cites this paper as [8]
Inhibition of aberrant STAT3 activation is a compelling target for HNSCC and CRC.
“the inhibition of aberrant STAT3 activation emerges as a compelling HNSCC and CRC target (8, 14, 15).”
From Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer (2022) · cites this paper as [8]
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References 65 · Cited by 374
- Authors
- Song, J. I., & Grandis, J. R.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Oncogene
- Published
- 2000-05-25
- Volume
- 19
- Issue
- 21
- Pages
- 2489-2495
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2016116775
- Cited by
- 374
- References
- 65
- Citations by year
- 2025: 4 · 2024: 10 · 2023: 5 · 2022: 3 · 2021: 12 · 2020: 7 · 2019: 2 · 2018: 12 · 2017: 13 · 2016: 14 · 2015: 16 · 2014: 17 · 2013: 10 · 2012: 19
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Keywords
- STAT3 signaling, head and neck squamous cell carcinoma, transforming growth factor-alpha, EGFR, field cancerization, carcinogenesis, autocrine signaling, Bcl-xL, apoptosis, growth inhibition, upper aerodigestive tract
- MeSH terms
- Cell Division, DNA-Binding Proteins, Head and Neck Neoplasms, Humans, Signal Transduction, Trans-Activators, Transforming Growth Factor alpha, RNA, Antisense, Apoptosis, STAT3 Transcription Factor, ErbB Receptors
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