Modulation of STAT signaling by STAT-interacting proteins
Abstract
STATs (signal transducer and activator of transcription) play important roles in numerous cellular processes including immune responses, cell growth and differentiation, cell survival and apoptosis, and oncogenesis. In contrast to many other cellular signaling cascades, the STAT pathway is direct: STATs bind to receptors at the cell surface and translocate into the nucleus where they function as transcription factors to trigger gene activation. However, STATs do not act alone. A number of proteins are found to be associated with STATs. These STAT-interacting proteins function to modulate STAT signaling at various steps and mediate the crosstalk of STATs with other cellular signaling pathways. This article reviews the roles of STAT-interacting proteins in the regulation of STAT signaling. Oncogene (2000).
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Other mechanisms such as PIAS may also play a role in inhibiting early cytokine signaling during PH.
“Other mechanisms such as PIAS (39) that downregulate cytokine signaling in other cells may also play a role in inhibiting early cytokine signaling during PH.”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [39]
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References 63 · Cited by 379
- Authors
- Shuai, K.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Shuai, K
- ORCID
- Shuai, K
- Venue
- Oncogene
- Published
- 2000-05-25
- Volume
- 19
- Issue
- 21
- Pages
- 2638-2644
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W1983974405
- Cited by
- 379
- References
- 63
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 7 · 2018: 11 · 2017: 7 · 2016: 7 · 2015: 14 · 2014: 13 · 2013: 17 · 2012: 8
- FWCI
- 13.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- STAT signaling, signal transducer and activator of transcription, transcription factors, signal transduction, signaling crosstalk, nuclear translocation, gene expression regulation, carcinogenesis
- MeSH terms
- Animals, Carrier Proteins, DNA-Binding Proteins, Fungal Proteins, Humans, Ligases, Protein Binding, Proteins, Transcription Factors, Signal Transduction, Trans-Activators, Cell Cycle Proteins, Mitogen-Activated Protein Kinases, Schizosaccharomyces pombe Proteins, Ubiquitin-Protein Ligases, Intracellular Signaling Peptides and Proteins, STAT1 Transcription Factor, Protein Inhibitors of Activated STAT
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