Ets target genes: past, present and future
Abstract
Ets is a family of transcription factors present in species ranging from sponges to human. All family members contain an approximately 85 amino acid DNA binding domain, designated the Ets domain. Ets proteins bind to specific purine-rich DNA sequences with a core motif of GGAA/T, and transcriptionally regulate a number of viral and cellular genes. Thus, Ets proteins are an important family of transcription factors that control the expression of genes that are critical for several biological processes, including cellular proliferation, differentiation, development, transformation, and apoptosis. Here, we tabulate genes that are regulated by Ets factors and describe past, present and future strategies for the identification and validation of Ets target genes. Through definition of authentic target genes, we will begin to understand the mechanisms by which Ets factors control normal and abnormal cellular processes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TEL has a classic Ets domain in the C terminus and binds to the Ets site with a core motif of GGAA/T.
“TEL has a classic Ets domain in the C terminus and binds to the Ets site, with a core motif of GGAA/T (44).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [44]
The citation lists haven’t been fetched yet
References 332 · Cited by 371
- Authors
- Sementchenko, V. I., & Watson, D. K.
- Affiliations
- Medical University of South Carolina (US)
- ORCID
- Watson, Dennis K
- Venue
- Oncogene
- Published
- 2000-12-18
- Volume
- 19
- Issue
- 55
- Pages
- 6533-6548
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2082214219
- Cited by
- 371
- References
- 332
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 11 · 2021: 13 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 13 · 2013: 14 · 2012: 15
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- National Cancer Institute (CA78582, P01CA078582)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- ETS transcription factors, ETS domain, target gene identification, transcriptional regulation, cell proliferation, differentiation, apoptosis, oncogenic transformation, gene expression regulation
- MeSH terms
- Animals, Binding Sites, Cell Transformation, Neoplastic, Cell Transformation, Viral, Chromatin, DNA, Embryonic and Fetal Development, Forecasting, Gene Expression Regulation, Genes, Multigene Family, Genes, Viral, Genetic Techniques, Hematopoiesis, Humans, Mice, Transgenic, Oncogenes, Precipitin Tests, Promoter Regions, Genetic, Protein Binding, Proteins, Transcription Factors, Transcription, Genetic, Mice, Knockout, Gene Expression Profiling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
