CoChat
Sign Up
Cited by 245Cell death mechanisms and regulationMitochondrial Function and PathologyRedox biology and oxidative stress

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

The adenine nucleotide translocator: a target of nitric oxide, peroxynitrite, and 4-hydroxynonenal

Vieira, Helena LA, Belzacq, Anne-Sophie, Haouzi, Delphine, Bernassola, Francesca, Cohen, Isabel, Jacotot, Etienne, Ferri, Karine F, El Hamel, Chahrazed, Bartle, Laura M, Melino, Gerry, Brenner, Catherine, Goldmacher, Victor, Kroemer, Guido·2001·Oncogene
DOI 10.1038/sj.onc.1204575
Open this paper in CoChat — free account

Abstract

Nitric oxide (NO), peroxynitrite, and 4-hydroxynonenal (HNE) may be involved in the pathological demise of cells via apoptosis. Apoptosis induced by these agents is inhibited by Bcl-2, suggesting the involvement of mitochondria in the death pathway. In vitro, NO, peroxynitrite and HNE can cause direct permeabilization of mitochondrial membranes, and this effect is inhibited by cyclosporin A, indicating involvement of the permeability transition pore complex (PTPC) in the permeabilization event. NO, peroxynitrite and HNE also permeabilize proteoliposomes containing the adenine nucleotide translocator (ANT), one of the key components of the PTPC, yet have no or little effects on protein-free control liposomes. ANT-dependent, NO-, peroxynitrite- or HNE-induced permeabilization is at least partially inhibited by recombinant Bcl-2 protein, as well as the antioxidants trolox and butylated hydroxytoluene. In vitro, none of the tested agents (NO, peroxynitrite, HNE, and tert-butylhydroperoxide) causes preferential carbonylation HNE adduction, or nitrotyrosylation of ANT. However, all these agents induced ANT to undergo thiol oxidation/derivatization. Peroxynitrite and HNE also caused significant lipid peroxidation, which was antagonized by butylated hydroxytoluene but not by recombinant Bcl-2. Transfection-enforced expression of vMIA, a viral apoptosis inhibitor specifically targeted to ANT, largely reduces the mitochondrial and nuclear signs of apoptosis induced by NO, peroxynitrite and HNE in intact cells. Taken together these data suggest that NO, peroxynitrite, and HNE may directly act on ANT to induce mitochondrial membrane permeabilization and apoptosis.

Overview

Integrity signals

Registry

Crossref · 10.1038/sj.onc.1204575

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Cited by

Sorted by citations

See all 245

Related

See all

Metadata

Authors
Vieira, H. L., Belzacq, A.-S., Haouzi, D., Bernassola, F., Cohen, I., Jacotot, E., Ferri, K. F., El Hamel, C., Bartle, L. M., Melino, G., Brenner, C., Goldmacher, V., & Kroemer, G.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Université de Technologie de Compiègne (FR)
  • University of Rome Tor Vergata (IT)
Corresponding author
Kroemer, Guido
ORCID
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2001-07-19
Volume
20
Issue
32
Pages
4305-4316
ISSN
  • 0950-9232 (ISSN-L)
  • 1476-5594
DOI
10.1038/sj.onc.1204575
OpenAlex
W2005480061
Cited by
244
References
67
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 10 · 2012: 16
FWCI
6.75
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Oncogene (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Funders
  • Agence Nationale de la Recherche
  • Ligue Contre le Cancer
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
adenine nucleotide translocase, nitric oxide, peroxynitrite, 4-hydroxynonenal, apoptosis, mitochondrial permeability transition pore, mitochondrial membrane permeabilization, Bcl-2, lipid peroxidation, thiol oxidation, Trolox, butylated hydroxytoluene, cyclosporine, oxidative stress
MeSH terms
Mitochondrial Permeability Transition Pore, Mitochondrial ADP, ATP Translocases, Aldehydes, Animals, Cell Nucleus, HeLa Cells, Humans, Intracellular Membranes, Ion Channels, Membrane Proteins, Mitochondria, Nitrates, Nitric Oxide, Permeability, Proteins, Proteolipids, Lipid Peroxidation, Oxidants, Apoptosis, Jurkat Cells, Proto-Oncogene Proteins c-bcl-2, Mitochondrial Membrane Transport Proteins, Inhibitor of Apoptosis Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review