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Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis
Abstract
The growth of human breast tumor cells is regulated through signaling involving cell surface growth factor receptors and nuclear receptors of the steroid/thyroid/retinoid receptor gene family. Retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor gene family, are ligand-dependent transcription factors, which have in vitro and in vivo growth inhibitory activity against breast cancer cells. RAR-agonists inhibit the proliferation of many human breast cancer cell lines, particularly those whose growth is stimulated by estradiol (E2) or growth factors. Additionally, RAR-agonists and synthetic retinoids such as Ferentinide have been shown to induce apoptosis in malignant breast cells but not normal breast cells. To better define the genes involved in RAR-mediated growth inhibition of breast cancer cells, we used oligonucleotide microarray analysis to create a database of genes that are potentially regulated by RAR-agonists in breast cancer cells. We found that PDCD4 (programmed cell death 4), a tumor suppressor gene presently being evaluated as a target for chemoprevention, was induced about three-fold by the RARalpha-selective agonist Am580, in T-47D breast cancer cells. RAR pan-agonists and Am580, but not retinoid X receptors (RXR)-agonists, stimulate the expression of PDCD4 in a wide variety of retinoid-inhibited breast cancer cell lines. RAR-agonists did not induce PDCD4 expression in breast cancer cell lines, which were not growth inhibited by retinoi…
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“its loss is diagnostic for human cancer staging and prognostic for survival in colon, lung, liver, breast, glioma and esophageal cancers (6–11).”
From Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65 (2014) · cites this paper as [6]
In the citing paper
“PDCD4 is a pro-apoptotic tumor suppressor gene and has been verified as a miR-21 target in human colorectal and breast cancer cell lines (Afonja et al., 2004; Asangani et al., 2007; Bitomsky et al., 2008; Frankel et al., 2007; Lu et al., 2008; Zhang et al., 2006).”
From Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21 (2010) · cites this paper as Afonja et al., 2004
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Greenlee, R. T., Murray, T., Bolden, S., & Wingo, P. A. (2000) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.50.1.7 · Cited by 3,850
ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics
McPherson, K. (2000) · BMJ · doi:10.1136/bmj.321.7261.624 · Cited by 1,570
Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.Preprint
Mangelsdorf, D. J., Borgmeyer, U., Heyman, R. A., Zhou, J. Y., Ong, E. S., Oro, A. E., Kakizuka, A., & Evans, R. M. (1992) · Genes & Development · doi:10.1101/gad.6.3.329 · Cited by 1,193
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.
Allenby, G., Bocquel, M. T., Saunders, M., Kazmer, S., Speck, J., Rosenberger, M., Lovey, A. J., Kastner, P., Grippo, J. F., & Chambon, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.30 · Cited by 755
Yang, H.-S., Jansen, A. P., Komar, A. A., Zheng, X., Merrick, W. C., Costes, S., Lockett, S. J., Sonenberg, N., & Colburn, N. H. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.26-37.2003 · Cited by 494
Retinoids and their receptors in cancer development and chemoprevention
Sun, S., & Lotan, R. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00144-5 · Cited by 324
A new class of retinoids with selective inhibition of AP-1 inhibits proliferation
Fanjul, A. N., Dawson, M. I., Hobbs, P. D., Jong, L., Cameron, J. F., Harlev, E., Graupner, G., Lu, X. P., & Pfahl, M. (1994) · Nature · doi:10.1038/372107a0 · Cited by 313
Molecular targets for breast cancer therapy and prevention
Bange, J., Zwick, E., & Ullrich, A. (2001) · Nature Medicine · doi:10.1038/87872 · Cited by 291
Research works printed but not linked: 2
- Chomczynski P and Sacchi N . (1987). Anal. Biochem., 162, 156–159. · DOI
- Jansen AP, Dean M and Colburn NH . (2003). Proc. Amer. Assoc. Cancer Res., 44, 938 (Abstract #4723).
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Items 101–153 of 153
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Kim, Y., Kwon, J.-T., Choi, J., Jiang, H.-L., Arote, R. B., Jere, D., Je, Y. H., Cho, M.-H., & Cho, C.-S. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.28 · Cited by 17
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Xu, S., Sun, A., & Suchy, F. J. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00138.2013 · Cited by 14
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Gedawy, G. A. E., Obada, M., Kelani, A., El‐Said, H., & Ghanayem, N. M. (2016) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2016.04.007 · Cited by 15
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Ding, L., Zhang, X., Zhao, M., Qu, Z., Huang, S., Dong, M., & Gao, F. (2011) · Medical Oncology · doi:10.1007/s12032-011-0042-6 · Cited by 12
Das, S., Nwachukwu, J. C., Li, D., Vulin, A. I., Martinez‐Caballero, S., Kinnally, K. W., & Samuels, H. H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4034 · Cited by 12
Self-citationDou, X., Wang, R.-B., Meng, X., Yan, H., Jiang, S., Zhu, K., Xu, X., Chen, D., Song, X., & Mu, D. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.2.825 · Cited by 11
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Liu, Y., Su, D., & Song, T. (2017) · RSC Advances · doi:10.1039/c7ra02000g · Cited by 7
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Wang, Y., Ding, L., Zhang, X., Zhao, M., Qu, Z., Huang, S., Zhang, Y., Li, Y., & Gao, F. (2012) · Medical Oncology · doi:10.1007/s12032-012-0185-0 · Cited by 5
Yasuda, M. T., Irie, K., & Murakami, A. (2010) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90892 · Cited by 5
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Lu, P., Yang, X., Yang, Y., Wang, F., Lin, L., & Gu, Y. (2018) · RSC Advances · doi:10.1039/c8ra00296g · Cited by 5
RetractedLiu, Y., Sun, H., Mao, H., Gao, M., Tan, X., Li, Y., Li, Y., Guy, M. M., Zhang, L., Wang, X., et al. (2018) · Oncology Letters · doi:10.3892/ol.2018.8517 · Cited by 5
Enikeev, A. D., Komelkov, A. V., Akselrod, M. E., & Tchevkina, E. M. (2019) · Russian Journal of Biotherapy · doi:10.17650/1726-9784-2019-18-4-43-50 · Cited by 5
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Xu, L., Yuan, H., Wang, Z., Zhao, S., & Yang, Y. (2022) · Genes · doi:10.3390/genes13122398 · Cited by 4
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Yang, H., Wang, Q., Bajer, M. M., & Schmid, T. (2014) · Springer eBooks · doi:10.1007/978-94-017-9078-9_6 · Cited by 3
Haffez, H., & Sayed, A. (2025) · Gene Reports · doi:10.1016/j.genrep.2025.102145 · Cited by 2
Enikeev, A. D., Komelkov, A. V., Elkina, N. V., Akselrod, M. E., Kuzmichev, S. A., & Tchevkina, E. M. (2022) · Advances in molecular oncology · doi:10.17650/2313-805x-2022-9-2-66-78 · Cited by 2
Proceedings on The Expression of Tumor Suppressor Gene Pdcd4 and Ubiquitin Pathway of Pdcd4 Protein
Chun-Ming, C. A. O., & Sun, Z. (2010) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2009.00597 · Cited by 1
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Wright, E. P., Lyons, V. G., Wang, S., & Higgins, V. J. (2011) · Springer eBooks · doi:10.1007/978-3-211-99079-7_13
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Willmert, L. J. (2004) · doi:10.21236/ada425991
Vreeland, A. C. (2015) · OhioLink ETD Center (Ohio Library and Information Network)
Sharma, S. B. (2015) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.6619
Tomenson, M. (2010) · TSpace (University of Toronto)
Parsyan, A. E., Gonzalez-Angulo, A. M., Zardavas, D., Piccart, M. J., & Meterissian, S. H. (2014) · Springer eBooks · doi:10.1007/978-94-017-9078-9_26
Tinnikov, A. A., Yeung, K. T., Das, S., & Samuels, H. H. (2023) · doi:10.1158/0008-5472.c.6499350.v1
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Mora, S., Alihemmat, L., Davari, L. D., Ataie, T., Mehranjani, P. N., Flewwelling, L. D., Cheng, A. J., & Adegoke, O. A. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.24.684280
Myofibrillar protein accumulation but reduced protein synthesis in PDCD4-depleted myotubes
Mora, S., Alihemmat, L., Davari, L. D., Ataie, T., Mehranjani, P. N., Flewwelling, L. D., Cheng, A. J., & Adegoke, O. A. J. (2026) · PLoS ONE · doi:10.1371/journal.pone.0345305
Shahin, Y. R., Guindy, N. M. E., Ghareeb, D. A., Elabd, S., & Balbaa, M. (2026) · Pharmaceuticals · doi:10.3390/ph19101513
Programmed cell death protein 4 (PDCD4): a pleiotropic regulator in cardiovascular diseases
Zheng, M., & Jiang, X. (2026) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-026-01237-4
Metadata
- Authors
- Afonja, O., Juste, D., Das, S., Matsuhashi, S., & Samuels, H. H.
- Affiliations
- New York University (US)
- Saga University (JP)
- Corresponding author
- Afonja, Olubunmi
- ORCID
- Das, Sharmistha
- Venue
- Oncogene
- Published
- 2004-09-13
- Volume
- 23
- Issue
- 49
- Pages
- 8135-8145
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2071878775
- Cited by
- 154
- References
- 47
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 5 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 9
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Robert Wood Johnson Foundation
- National Cancer Institute (K12 CA 01713, K12CA001713)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK16636)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- PDCD4, retinoic acid receptor agonists, breast cancer, apoptosis, tumor suppressor gene expression, antiestrogens, trastuzumab, AM580, retinoids, gene expression profiling, T47D cells, MDA-MB-231 cells, chemoprevention, retinoid X receptor
- MeSH terms
- Breast Neoplasms, Cell Cycle, Estrogen Antagonists, Humans, Transcription Factors, Gene Expression Regulation, Neoplastic, RNA-Binding Proteins, Apoptosis, Receptors, Retinoic Acid, Receptor, ErbB-2, Erb-b2 Receptor Tyrosine Kinases, Cell Line, Tumor, Retinoid X Receptors, Apoptosis Regulatory Proteins
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