Cited by 667Cancer and biochemical researchRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

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CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

Elchuri, Sailaja, Oberley, Terry D, Qi, Wenbo, Eisenstein, Richard S, Jackson Roberts, L, Van Remmen, Holly, Epstein, Charles J, Huang, Ting-Ting·2005·Oncogene

DOI 10.1038/sj.onc.1208207

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Abstract

Mice deficient in CuZn superoxide dismutase (CuZnSOD) showed no overt abnormalities during development and early adulthood, but had a reduced lifespan and increased incidence of neoplastic changes in the liver. Greater than 70% of Sod1-/- mice developed liver nodules that were either nodular hyperplasia or hepatocellular carcinoma (HCC). Cross-sectional studies with livers collected from Sod1-/- and age-matched +/+ controls revealed extensive oxidative damage in the cytoplasm and, to a lesser extent, in the nucleus and mitochondria from as early as 3 months of age. A marked reduction in cytosolic aconitase, increased levels of 8-oxo dG and F2-isoprostanes, and a moderate reduction in glutathione peroxidase activities and porin levels were observed in all age groups of Sod1-/- mice examined. There were also age-related reductions in Mn superoxide dismutase activities and carbonic anhydrase III. Parallel to the biochemical changes, there were progressive increases in the DNA repair enzyme APEX1, the cell cycle control proteins cyclin D1 and D3, and the hepatocyte growth factor receptor Met. Increased cell proliferation in the presence of persistent oxidative damage to macromolecules likely contributes to hepatocarcinogenesis later in life.

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[13] Catalase in vitro
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · cited 2×
“Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide (Murray and Lopez, 1997; Levy et al., 2002) and accounts for approximately 84% of all liver cancers.”
Background
Superoxide radical and superoxide dismutases
Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455
[37] Carbonyl assays for determination of oxidatively modified proteins
Levine, R. L., Williams, J. A., Stadtman, E. R., & Shacter, E. B. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33040-9 · Cited by 2,707
Mechanisms of Hepatotoxicity
Jaeschke, H. (2002) · Toxicological Sciences · doi:10.1093/toxsci/65.2.166 · Cited by 1,308
Cytochromes P450 and metabolism of xenobiotics
Anzenbacher, P., & Anzenbacherová, E. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000897 · Cited by 890
Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals
Pigeolet, E., Corbisier, P., Houbion, A., Lambert, D., Michiels, C., Raes, M. J., Zachary, M.-D., & Remacle, J. (1990) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(90)90078-t · Cited by 747
A Fraction of Yeast Cu,Zn-Superoxide Dismutase and Its Metallochaperone, CCS, Localize to the Intermembrane Space of Mitochondria
Sturtz, L. A., Diekert, K., Jensen, L. T., Lill, R., & Culotta, V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105296200 · Cited by 735
Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice
Chisari, F. V., Klopchin, K., Moriyama, T., Pasquinelli, C., Dunsford, H. A., Sell, S., Pinkert, C. A., Brinster, R. L., & Palmiter, R. D. (1989) · Cell · doi:10.1016/0092-8674(89)90770-8 · Cited by 696
Carbonyl modified proteins in cellular regulation, aging, and disease2,3 2Guest Editor: Earl Stadtman 3This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.
Levine, R. L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00765-7 · Cited by 675

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Doğan, M., Teralı, K., Eröz, R., Kılıç, H., Gezdirici, A., & Gönüllü, B. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09513-6 · Cited by 9
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Otsuki, N., Homma, T., Fujiwara, H., Kaneko, K., Hozumi, Y., Shichiri, M., Takashima, M., Ito, J., Konno, T., Kurahashi, T., et al. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.05.007 · Cited by 9
Construction of a fusion enzyme exhibiting superoxide dismutase and peroxidase activity
Sharapov, M. G., Novoselov, V. I., & Ravin, V. K. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916040131 · Cited by 9
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Chang, Y., Zhang, Z., Wu, B., Zhao, H. Y., Liu, G., Chen, X., Tian, G., Cai, J., & Jia, G. (2021) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2021.114875 · Cited by 9
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Zhang, L., Qiang, L., Chen, F., Wu, T., Rong, J., Zhao, Q., Zou, M., Yang, Z., You, Q., Li, Z., et al. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.067 · Cited by 9
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Tridente, G., Jana, A., Nath, A., & Ashraf, G. M. (2023) · Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders · doi:10.1016/b978-0-443-18677-6.00015-4 · Cited by 8
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Castelli, S., Aiello, G., Aiello, V., Massimino, E., Pieri, M., Amoah, I., Lombardo, M., Tripodi, G., & Baldelli, S. (2026) · Molecules · doi:10.3390/molecules31050756 · Cited by 9
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Zhou, Y., Lu, N., Zhang, H., Wei, L., Tao, L., Dai, Q., Zhao, L., Lin, B., Ding, Q., & Guo, Q. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.04.016 · Cited by 8
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Manzoor, S., Khalid, M., & Idrees, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0259727 · Cited by 7
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Feng, Z., Wu, R., Lin, M., & Hu, W. (2011) · Frontiers in Biology · doi:10.1007/s11515-011-0970-8 · Cited by 7
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Brzóska, K., Sochanowicz, B., Siomek, A., Oliński, R., & Kruszewski, M. K. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0781-x · Cited by 7
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Moustafa, S. R. (2015) · Cancer Research Journal · doi:10.11648/j.crj.20150302.11 · Cited by 7
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Geng, A., Wang, X., Wu, Z., Liu, Z., Huang, X. H., Wang, X., Sun, X., Wang, Y., Chen, J., Jiang, Y., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103770 · Cited by 6
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Authors: Elchuri, S., Oberley, T. D., Qi, W., Eisenstein, R. S., Jackson Roberts, L., Van Remmen, H., Epstein, C. J., & Huang, T.-T.
Affiliations: Stanford University (US)
University of Wisconsin–Madison (US)
The University of Texas at San Antonio Health Science Center (US)
University of California, San Francisco (US)
VA Palo Alto Health Care System (US)
Corresponding author: Huang, Ting-Ting
ORCID: Elchuri, Sailaja
Qi, Wenbo
Eisenstein, Richard S
Epstein, Charles J
Huang, Ting-Ting
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2004-11-08
Volume: 24
Issue: 3
Pages: 367-380
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1208207
OpenAlex: W2042637324
Cited by: 667
References: 72
Citations by year: 2026: 11 · 2025: 22 · 2024: 24 · 2023: 27 · 2022: 32 · 2021: 25 · 2020: 24 · 2019: 24 · 2018: 25 · 2017: 31 · 2016: 29 · 2015: 35 · 2014: 48 · 2013: 48 · 2012: 45
FWCI: 5.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG16998, R01AG016998, R01AG016633, AG16633)
National Institute of General Medical Sciences (GM 15431, GM 42056)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-26657, DK47219, P30DK026657)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: Cu/Zn superoxide dismutase, Sod1 knockout mice, hepatocarcinogenesis, oxidative damage, liver nodules, hepatocellular carcinoma, nodular hyperplasia, aconitase, 8-oxoguanine, F2-isoprostanes, glutathione peroxidase, Mn superoxide dismutase, carbonic anhydrase III, APEX1, DNA repair, cyclin D1, cyclin D3, c-Met, hepatocyte proliferation, aging
MeSH terms: Aging, Animals, Cell Nucleus, Liver, Liver Neoplasms, Mitochondria, Superoxide Dismutase, Mice, Knockout, Oxidative Stress, Mice

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CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

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