Molecular Aspects of Tanning
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MITF controls UVB-induced expression of pigmentation genes and DNA repair and proliferation genes in melanoma cells.
“MITF controls UVB-induced expression of pigmentation genes32 and DNA repair and proliferation genes in melanoma cells51,52.”
From Mechanisms and prevention of <scp>UV</scp>‐induced melanoma (2018) · cites this paper as [32]
UVB induces expression of pigmentation-related genes in melanocytes, including αMSH and MC1R.
“UVB induces expression of a number of pigmentation-related genes in melanocytes44, including αMSH and MC1R expression32.”
From Mechanisms and prevention of <scp>UV</scp>‐induced melanoma (2018) · cites this paper as [32]
Eumelanin is the most common melanin in dark skin and hair and is synthesized when αMSH binds MC1R.
“Eumelanin is the most common type in dark skin and dark hair, and is synthesized upon binding of α-melanocyte-stimulating hormone (αMSH) to melanocortin-1 receptor (MC1R)32.”
From Mechanisms and prevention of <scp>UV</scp>‐induced melanoma (2018) · cites this paper as [32]
Downstream of MC1R, cAMP signaling activates the transcription factor MITF.
“Downstream of MC1R, cAMP signaling activates transcription factor MITF32.”
From Mechanisms and prevention of <scp>UV</scp>‐induced melanoma (2018) · cites this paper as [32]
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Cites
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., & de Lange, T. (1999) · Science · doi:10.1126/science.283.5406.1321 · Cited by 1,086 · see citing works
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Adoptive immunotherapy for cancer: harnessing the T cell response
Restifo, N. P., Dudley, M. E., & Rosenberg, S. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3191 · Cited by 1,688 · see citing works
Mechanisms and prevention of <scp>UV</scp>‐induced melanoma
Sample, A., & He, Y. (2018) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/phpp.12329 · Cited by 372 · see citing works
- Authors
- Gilchrest, B. A.
- Affiliations
- Boston University (US)
- Corresponding author
- Gilchrest, Barbara A.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 131
- Issue
- E1
- Pages
- E14-E17
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2237570137
- Cited by
- 30
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- tanning, melanization, epidermis, ultraviolet radiation, UV damage, host response, skin pigmentation, melanin, sharks, mammals
- MeSH terms
- Epidermal Cells, Animals, DNA Damage, Epidermis, Humans, Melanins, Monophenol Monooxygenase, Ultraviolet Rays, Tumor Suppressor Protein p53, Telomere, Models, Animal, Mice, Sunbathing
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