The DOI matches its Crossref record.
Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus
Open accessAbstract
HCV NS3 protein plays a central role in viral polyprotein processing and RNA replication. We demonstrate that the NS3 protease (NS3(pro)) domain alone can specifically bind to HCV-IRES RNA, predominantly in the SLIV region. The cleavage activity of the NS3 protease domain is reduced upon HCV-RNA binding. More importantly, NS3(pro) binding to the SLIV hinders the interaction of La protein, a cellular IRES-trans acting factor required for HCV IRES-mediated translation, resulting in inhibition of HCV-IRES activity. Although overexpression of both NS3(pro) as well as the full length NS3 protein decreased the level of HCV IRES mediated translation, replication of HCV replicon RNA was enhanced significantly. These observations suggest that the NS3(pro) binding to HCV IRES reduces translation in favor of RNA replication. The competition between the host factor (La) and the viral protein (NS3) for binding to HCV IRES might regulate the molecular switch from translation to replication of HCV.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Hammock, M. L., Chortos, A., Tee, B. C. ‐., Tok, J. B. ‐., & Bao, Z. (2013) · Advanced Materials · doi:10.1002/adma.201302240 · Cited by 2,396
Quantum simulations with ultracold quantum gases
Bloch, I., Dalibard, J., & Nascimbène, S. (2012) · Nature Physics · doi:10.1038/nphys2259 · Cited by 2,339
Shiferaw, B., Prasanna, B. M., Hellin, J., & Bänziger, M. (2011) · Food Security · doi:10.1007/s12571-011-0140-5 · Cited by 1,612
Shiferaw, B., Smale, M., Braun, H.-J., Duveiller, E., Reynolds, M., & Muricho, G. (2013) · Food Security · doi:10.1007/s12571-013-0263-y · Cited by 1,445
Genomic basis for coral resilience to climate change
Barshis, D. J., Ladner, J. T., Oliver, T. A., Seneca, F. O., Traylor-Knowles, N., & Palumbi, S. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210224110 · Cited by 909
Metadata
- Authors
- Ray, U., & Das, S.
- Venue
- Scientific Reports
- Published
- 2011-06-14
- Volume
- 1
- Issue
- 1
- Pages
- 1-1
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2078167976
- Cited by
- 884
- References
- 0
- FWCI
- 38.30
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus. https://app.cochat.ai/papers/10.1038/srep00001
- The paper
- Ray, U., & Das, S. (2011). Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus. Scientific Reports. https://doi.org/10.1038/srep00001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
