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Biodegradability engineering of biodegradable Mg alloys: Tailoring the electrochemical properties and microstructure of constituent phases
Open accessAbstract
Crystalline Mg-based alloys with a distinct reduction in hydrogen evolution were prepared through both electrochemical and microstructural engineering of the constituent phases. The addition of Zn to Mg-Ca alloy modified the corrosion potentials of two constituent phases (Mg + Mg2Ca), which prevented the formation of a galvanic circuit and achieved a comparable corrosion rate to high purity Mg. Furthermore, effective grain refinement induced by the extrusion allowed the achievement of much lower corrosion rate than high purity Mg. Animal studies confirmed the large reduction in hydrogen evolution and revealed good tissue compatibility with increased bone deposition around the newly developed Mg alloy implants. Thus, high strength Mg-Ca-Zn alloys with medically acceptable corrosion rate were developed and showed great potential for use in a new generation of biodegradable implants.
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Cited by
Biodegradable magnesium-based implants in orthopedics-a general review and perspectives
Wang, J., Xu, J., Hopkins, C., Chow, D. H., & Qin, L. (2020) · Advanced Science · doi:10.1002/advs.201902443 · Cited by 574
Insight of magnesium alloys and composites for orthopedic implant applications – a review
Radha, R., & Sreekanth, D. (2017) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2017.08.003 · Cited by 533
Li, X., Liu, X., Wu, S., Yeung, K. W. K., Zheng, Y., & Chu, P. K. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.09.005 · Cited by 428
Influence of Ca and Zn on the microstructure and corrosion of biodegradable Mg–Ca–Zn alloys
Zander, D., & Zumdick, N. A. (2015) · Corrosion Science · doi:10.1016/j.corsci.2015.01.027 · Cited by 260
Metadata
- Authors
- Cha, P.-R., Han, H.-S., Yang, G.-F., Kim, Y.-C., Hong, K.-H., Lee, S.-C., Jung, J.-Y., Ahn, J.-P., Kim, Y.-Y., Cho, S.-Y., Byun, J. Y., Lee, K.-S., Yang, S.-J., & Seok, H.-K.
- Venue
- Scientific Reports
- Published
- 2013-08-06
- Volume
- 3
- Issue
- 1
- Pages
- 2367-2367
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2029311092
- Cited by
- 206
- References
- 0
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cha, P.-R., Han, H.-S., Yang, G.-F., Kim, Y.-C., Hong, K.-H., Lee, S.-C., Jung, J.-Y., Ahn, J.-P., Kim, Y.-Y., Cho, S.-Y., Byun, J. Y., Lee, K.-S., Yang, S.-J., & Seok, H.-K. (2013). Biodegradability engineering of biodegradable Mg alloys: Tailoring the electrochemical properties and microstructure of constituent phases. Scientific Reports. https://doi.org/10.1038/srep02367
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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