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Understanding the antimicrobial mechanism of TiO2-based nanocomposite films in a pathogenic bacterium
Open accessAbstract
Titania (TiO₂)-based nanocomposites subjected to light excitation are remarkably effective in eliciting microbial death. However, the mechanism by which these materials induce microbial death and the effects that they have on microbes are poorly understood. Here, we assess the low dose radical-mediated TiO₂ photocatalytic action of such nanocomposites and evaluate the genome/proteome-wide expression profiles of Pseudomonas aeruginosa PAO1 cells after two minutes of intervention. The results indicate that the impact on the gene-wide flux distribution and metabolism is moderate in the analysed time span. Rather, the photocatalytic action triggers the decreased expression of a large array of genes/proteins specific for regulatory, signalling and growth functions in parallel with subsequent selective effects on ion homeostasis, coenzyme-independent respiration and cell wall structure. The present work provides the first solid foundation for the biocidal action of titania and may have an impact on the design of highly active photobiocidal nanomaterials.
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Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0
Schellenberger, J., Que, R., Fleming, R. M. T., Thiele, I., Orth, J. D., Feist, A. M., Zielinski, D. C., Bordbar, A., Lewis, N. E., Rahmanian, S., et al. (2011) · Nature Protocols · doi:10.1038/nprot.2011.308 · Cited by 1,835
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Sharma, C., Dhiman, R., Rokana, N., & Panwar, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01735 · Cited by 389
Li, G., Nie, X., Chen, J., Jiang, Q., An, T., Wong, P. K., Zhang, H., Zhao, H., & Yamashita, H. (2015) · Water Research · doi:10.1016/j.watres.2015.05.053 · Cited by 370
Nanomaterials for agriculture, food and environment: applications, toxicity and regulation
Kaphle, A., Navya, P. N., Umapathi, A., & Daima, H. K. (2018) · Environmental Chemistry Letters · doi:10.1007/s10311-017-0662-y · Cited by 293
Interactions between Metal Oxides and Biomolecules: from Fundamental Understanding to Applications
Limo, M. J., Sola-Rabada, A., Boix, E., Thota, V., Westcott, Z. C., Puddu, V., & Perry, C. C. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00660 · Cited by 287
Balasubramaniam, B., Prateek, Ranjan, S., Saraf, M., Kar, P., Singh, S. P., Thakur, V. K., Singh, A., & Gupta, R. K. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00174 · Cited by 285
Metadata
- Authors
- Kubacka, A., Diez, M. S., Rojo, D., Bargiela, R., Ciordia, S., Zapico, I., Albar, J. P., Barbas, C., Martins dos Santos, V. A. P., Fernández-García, M., & Ferrer, M.
- Venue
- Scientific Reports
- Published
- 2014-02-19
- Volume
- 4
- Issue
- 1
- Pages
- 4134-4134
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2045388510
- Cited by
- 426
- References
- 1
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kubacka, A., Diez, M. S., Rojo, D., Bargiela, R., Ciordia, S., Zapico, I., Albar, J. P., Barbas, C., Martins dos Santos, V. A. P., Fernández-García, M., & Ferrer, M. (2014). Understanding the antimicrobial mechanism of TiO2-based nanocomposite films in a pathogenic bacterium. Scientific Reports. https://doi.org/10.1038/srep04134
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