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Cited by 733

The DOI matches its Crossref record.

Correction: Corrigendum: Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo

Open access
Donnelley, Martin, Morgan, Kaye S., Siu, Karen K. W., Farrow, Nigel R., Stahr, Charlene S., Boucher, Richard C., Fouras, Andreas, Parsons, David W.·2014·Scientific Reports
DOI 10.1038/srep05361
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Abstract

To determine the efficacy of potential cystic fibrosis (CF) therapies we have developed a novel mucociliary transit (MCT) measurement that uses synchrotron phase contrast X-ray imaging (PCXI) to non-invasively measure the transit rate of individual micron-sized particles deposited into the airways of live mice. The aim of this study was to image changes in MCT produced by a rehydrating treatment based on hypertonic saline (HS), a current CF clinical treatment. Live mice received HS containing a long acting epithelial sodium channel blocker (P308); isotonic saline; or no treatment, using a nebuliser integrated within a small-animal ventilator circuit. Marker particle motion was tracked for 20 minutes using PCXI. There were statistically significant increases in MCT in the isotonic and HS-P308 groups. The ability to quantify in vivo changes in MCT may have utility in pre-clinical research studies designed to bring new genetic and pharmaceutical treatments for respiratory diseases into clinical trials.

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Authors
Donnelley, M., Morgan, K. S., Siu, K. K. W., Farrow, N. R., Stahr, C. S., Boucher, R. C., Fouras, A., & Parsons, D. W.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2014-07-16
Volume
4
Issue
1
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep05361
OpenAlex
W2602364388
Cited by
733
References
0
Type
journal article
Language
en
Open access
gold

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