Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury
Open accessAbstract
Since March 2013, the emergence of an avian-origin influenza A (H7N9) virus has raised concern in China. Although most infections resulted in respiratory illness, some severe cases resulted in acute respiratory distress syndrome (ARDS), which is a severe form of acute lung injury (ALI) that further contributes to morbidity. To date, no effective drugs that improve the clinical outcome of influenza A (H7N9) virus-infected patients have been identified. Angiotensin-converting enzyme (ACE) and ACE2 are involved in several pathologies such as cardiovascular functions, renal disease, and acute lung injury. In the current study, we report that ACE2 could mediate the severe acute lung injury induced by influenza A (H7N9) virus infection in an experimental mouse model. Moreover, ACE2 deficiency worsened the disease pathogenesis markedly, mainly by targeting the angiotensin II type 1 receptor (AT1). The current findings demonstrate that ACE2 plays a critical role in influenza A (H7N9) virus-induced acute lung injury, and suggest that might be a useful potential therapeutic target for future influenza A (H7N9) outbreaks.
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ACE2 is an important target for various CoV and influenza viruses.
“Meanwhile, ACE2 is also an important target for various CoV and influenza viruses (Turner et al., 2004, Wrapp et al., 2020, Yang et al., 2014).”
From Nervous system involvement after infection with COVID-19 and other coronaviruses (2020) · cites this paper as Yang et al., 2014
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References 26 · Cited by 283
- Authors
- Yang, P., Gu, H., Zhao, Z., Wang, W., Cao, B., Lai, C., Yang, X., Zhang, L., Duan, Y., Zhang, S., Chen, W., Zhen, W., Cai, M., Penninger, J. M., Jiang, C., & Wang, X.
- Affiliations
- Beijing Institute of Microbiology and Epidemiology (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Capital Medical University (CN)
- 302 Military Hospital of China (CN)
- Qingzhou City People's Hospital (CN)
- Institute of Molecular Biotechnology (AT)
- ORCID
- Venue
- Scientific Reports
- Published
- 2014-11-13
- Volume
- 4
- Issue
- 1
- Pages
- 7027-7027
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4229671
- OpenAlex
- W2042477769
- Cited by
- 283
- References
- 26
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 10 · 2023: 14 · 2022: 33 · 2021: 71 · 2020: 127 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 4
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Beijing Nova Program (Z141107001814054, No. Z141107001814054)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- angiotensin-converting enzyme 2, H7N9 avian influenza, acute lung injury, acute respiratory distress syndrome, angiotensin II type 1 receptor, avian influenza, therapeutic target, mouse model
- MeSH terms
- Angiotensin-Converting Enzyme 2, Animals, Antiviral Agents, Humans, Imidazoles, Peptidyl-Dipeptidase A, Lung, Mice, Inbred C57BL, Orthomyxoviridae Infections, Pyridines, Signal Transduction, Gene Expression, Survival Analysis, Viral Load, Losartan, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, Angiotensin II Type 1 Receptor Blockers, Mice, Acute Lung Injury, Angiotensin II Type 2 Receptor Blockers, Influenza A Virus, H7N9 Subtype
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