Monomeric C-reactive protein-a key molecule driving development of Alzheimer’s disease associated with brain ischaemia?
Open accessAbstract
Alzheimer’s disease (AD) increases dramatically in patients with ischaemic stroke. Monomeric C-reactive protein (mCRP) appears in the ECM of ischaemic tissue after stroke, associating with microvasculature, neurons and AD-plaques, Aβ, also, being able to dissociate native-CRP into inflammatory, mCRP in vivo. Here, mCRP injected into the hippocampal region of mice was retained within the retrosplenial tract of the dorsal 3rd ventrical and surrounding major vessels. Mice developed behavioural/cognitive deficits within 1 month, concomitant with mCRP staining within abnormal looking neurons expressing p-tau and in beta-amyloid 1-42-plaque positive regions. mCRP co-localised with CD105 in microvessels suggesting angiogenesis. Phospho-arrays/Western blotting identified signalling activation in endothelial cells and neurons through p-IRS-1, p-Tau and p-ERK1/2-which was blocked following pre-incubation with mCRP-antibody. mCRP increased vascular monolayer permeability and gap junctions, increased NCAM expression and produced haemorrhagic angiogenesis in mouse matrigel implants. mCRP induced tau244–372 aggregation and assembly in vitro. IHC study of human AD/stroke patients revealed co-localization of mCRP with Aβ plaques, tau-like fibrils and IRS-1/P-Tau positive neurons and high mCRP-levels spreading from infarcted core regions matched reduced expression of Aβ/Tau. mCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia.
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Monomeric CRP acts as a linker between vascular trauma and inflammation and is associated with plaque generation, neuronal injury, and dementia.
“Monomeric CRP acts as a linker between vascular trauma and inflammation and also is associated with other events like plaque generation, neuronal injury, and dementia [52].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [52]
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References 51 · Cited by 115
Research works printed but not linked: 5
- Garcia-Mesa Y.. Physical exercise protects against Alzheimer’s disease in 3xTg-AD mice. J. Alzheimer’s Dis. 24, 421– 454 (2011). 21297257
- Balczon R.. Pseudomonas aeruginosa exotoxin Y-mediated tau hyperphosphorylation impairs microtubule assembly in pulmonary microvascular endothelial cells. PLoS One. 8, e74343 (2013). 24023939 PMC3762819
- Rajas J.. Enhanced Aβ(1-40) production in endothelial cells stimulated with fibrillar Aβ(1-42). PLoS One. 8, e58194 (2013). 23505467 PMC3591408
- Mirra S. S.. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer’s disease. Neurology. 41, 479– 486 (1991). 2011243
- Braak H., Alafuzoff I., Arzberger T., Kretzschmar H. & Del Tredici K. Staging of Alzheimer’s disease-associated neurofibrillary pathologyusing paraffin sectionsand immunohistochemistry. Neuropathol. 112, 389– 404 (1996). PMC3906709 16906426
- Authors
- Slevin, M., Matou, S., Zeinolabediny, Y., Corpas, R., Weston, R., Liu, D., Boras, E., Di Napoli, M., Petcu, E., Sarroca, S., Popa-Wagner, A., Love, S., Font, M. A., Potempa, L. A., Al-baradie, R., Sanfeliu, C., Revilla, S., Badimon, L., & Krupinski, J.
- Affiliations
- Griffith University (AU)
- Manchester Metropolitan University (GB)
- Consejo Superior de Investigaciones Científicas (ES)
- University of Bristol (GB)
- Majmaah University (SA)
- Corresponding author
- Slevin, M.
- Venue
- Scientific Reports
- Published
- 2015-09-03
- Volume
- 5
- Issue
- 1
- Pages
- 13281-13281
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4558604
- OpenAlex
- W2208874007
- Cited by
- 115
- References
- 51
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 14 · 2023: 10 · 2022: 16 · 2021: 24 · 2020: 10 · 2019: 5 · 2018: 14 · 2017: 4 · 2016: 7
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- e-space (Manchester Metropolitan University) (acceptedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Griffith Research Online (submittedVersion, cc-by)
- Funders
- Banco Bilbao Vizcaya Argentaria
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- monomeric C-reactive protein, Alzheimer's disease, ischemic stroke, brain ischaemia, tau aggregation, amyloid plaques, tau phosphorylation, ERK signaling, angiogenesis, endothelial permeability, gap junctions, CD56, dementia, hippocampus, CD105
- MeSH terms
- Alzheimer Disease, Animals, Brain Ischemia, Male, Mice, Inbred C57BL, Neurons, Receptors, Immunologic, Biomarkers, Disease Progression, Mice
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