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Mycofabricated biosilver nanoparticles interrupt Pseudomonas aeruginosa quorum sensing systems
Open accessAbstract
Quorum sensing (QS) is a chemical communication process that Pseudomonas aeruginosa uses to regulate virulence and biofilm formation. Disabling of QS is an emerging approach for combating its pathogenicity. Silver nanoparticles (AgNPs) have been widely applied as antimicrobial agents against human pathogenic bacteria and fungi, but not for the attenuation of bacterial QS. Here we mycofabricated AgNPs (mfAgNPs) using metabolites of soil fungus Rhizopus arrhizus BRS-07 and tested their effect on QS-regulated virulence and biofilm formation of P. aeruginosa. Transcriptional studies demonstrated that mfAgNPs reduced the levels of LasIR-RhlIR. Treatment of mfAgNPs inhibited biofilm formation, production of several virulence factors (e.g. LasA protease, LasB elastrase, pyocyanin, pyoverdin, pyochelin, rhamnolipid and alginate) and reduced AHLs production. Further genes quantification analyses revealed that mfAgNPs significantly down-regulated QS-regulated genes, specifically those encoded to the secretion of virulence factors. The results clearly indicated the anti-virulence property of mfAgNPs by inhibiting P. aeruginosa QS signaling.
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Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Nafee, N., Husari, A., Maurer, C. K., Lu, C., de Rossi, C., Steinbach, A., Hartmann, R. W., Lehr, C.-M., & Schneider, M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.055 · Cited by 208
Metadata
- Authors
- Singh, B. R., Singh, B. N., Singh, A., Khan, W., Naqvi, A. H., & Singh, H. B.
- Venue
- Scientific Reports
- Published
- 2015-09-08
- Volume
- 5
- Issue
- 1
- Pages
- 13719-13719
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W1468589511
- Cited by
- 192
- References
- 2
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- gold
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- Singh, B. R., Singh, B. N., Singh, A., Khan, W., Naqvi, A. H., & Singh, H. B. (2015). Mycofabricated biosilver nanoparticles interrupt Pseudomonas aeruginosa quorum sensing systems. Scientific Reports. https://doi.org/10.1038/srep13719
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