The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren
Open accessAbstract
We report that the DNA methylation profile of a child’s neonatal whole blood can be significantly influenced by his or her mother’s neonatal blood lead levels (BLL). We recruited 35 mother-infant pairs in Detroit and measured the whole blood lead (Pb) levels and DNA methylation levels at over 450,000 loci from current blood and neonatal blood from both the mother and the child. We found that mothers with high neonatal BLL correlate with altered DNA methylation at 564 loci in their children’s neonatal blood. Our results suggest that Pb exposure during pregnancy affects the DNA methylation status of the fetal germ cells, which leads to altered DNA methylation in grandchildren’s neonatal dried blood spots. This is the first demonstration that an environmental exposure in pregnant mothers can have an epigenetic effect on the DNA methylation pattern in the grandchildren.
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Cites
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Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons
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Cited by
Hanna-Attisha, M., LaChance, J., Sadler, R. C., & Champney Schnepp, A. (2016) · American Journal of Public Health · doi:10.2105/ajph.2015.303003 · Cited by 1,119
Serpeloni, F., Radtke, K., de Assis, S. G., Henning, F., Nätt, D., & Elbert, T. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.153 · Cited by 98
Svoboda, L. K., Ishikawa, T., & Dolinoy, D. C. (2022) · Environmental Epigenetics · doi:10.1093/eep/dvac017 · Cited by 27
Metadata
- Authors
- Sen, A., Heredia, N., Senut, M.-C., Land, S., Hollocher, K., Lu, X., Dereski, M. O., & Ruden, D. M.
- Venue
- Scientific Reports
- Published
- 2015-09-29
- Volume
- 5
- Issue
- 1
- Pages
- 14466-14466
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2174782136
- Cited by
- 162
- References
- 12
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sen, A., Heredia, N., Senut, M.-C., Land, S., Hollocher, K., Lu, X., Dereski, M. O., & Ruden, D. M. (2015). Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren. Scientific Reports. https://doi.org/10.1038/srep14466
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