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Cited by 161MicroRNA in disease regulationAtherosclerosis and Cardiovascular DiseasesCholesterol and Lipid Metabolism

miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1

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Li, Xiaoyi, Kong, Deyong, Chen, Heming, Liu, Shuiyi, Hu, Hui, Wu, Tangwei, Wang, Jing, Chen, Weiqun +3 more·2016·Scientific Reports
DOI 10.1038/srep21789PMC PMC4761895
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Abstract

Atherosclerosis (AS) is chronic inflammation in response to lipid accumulation. MicroRNA-155 (miR-155) is being increasingly studied to evaluate its potential as diagnostic biomarkers and therapeutic targets in many diseases. However, delineating the role of miR-155 in AS remains difficult. Here, we detected constitutive expression of several microRNAs (miRNAs) possibly associated with cardiovascular disease in foam cells and clinical specimens from patients with AS. Among them, we found that the level of miR-155 in foam cells was the most significantly elevated in a dose- and time-dependent manner. In addition, the expression of miR-155 was elevated in the plasma and plaque of patients with AS. We also reported for the first time that miR-155 targets calcium-regulated heat stable protein 1 (CARHSP1), which regulates the stability of tumor necrosis factor alpha (TNF-α) mRNA. Furthermore, we investigated the mechanism by which the miR-155 level is elevated. miR-155 upregulation is due to transcriptional regulation by nuclear factor (NF)-κB, which is activated by the inflammatory factor TNF-α. In summary, increased miR-155 relieves chronic inflammation by a negative feedback loop and plays a protective role during atherosclerosis-associated foam cell formation by signaling through the miR-155–CARHSP1–TNF-α pathway.

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  • miR-155 can set the magnitude and timing of the pro-inflammatory response by targeting the 3'UTR of mRNAs that encode specific anti-inflammatory mediators.

    “miR-155 can set the magnitude and timing of the pro-inflammatory response by targeting the 3’UTR of mRNAs that encode specific anti-inflammatory mediators [18, 19].”

    From Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures (2023) · cites this paper as [18]

    The Abstract says miR-155 can promote atherosclerosis by relieving BCL6-mediated inhibition of CCL2, and describes 3′-UTR binding as the general mechanism of miRNAs. But the paper does not show that targeting anti-inflammatory mediators sets the magnitude or timing of a pro-inflammatory response. Its Results instead demonstrate miR-155 binding the CARHSP1 3′-UTR and suppressing TNF-α secretion in foam cells. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Authors
Li, X., Kong, D., Chen, H., Liu, S., Hu, H., Wu, T., Wang, J., Chen, W., Ning, Y., Li, Y., & Lu, Z.
Affiliations
  • Hubei University of Chinese Medicine (CN)
  • Central Hospital of Wuhan (CN)
  • Central South University (CN)
  • Cleveland Clinic (US)
Corresponding author
  • Li, Yong
  • Lu, Zhongxin
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2016-02-22
Volume
6
Issue
1
Pages
21789-21789
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/srep21789
PMC
PMC4761895
OpenAlex
W2277078417
Cited by
161
References
1
Citations by year
2026: 7 · 2025: 9 · 2024: 17 · 2023: 11 · 2022: 13 · 2021: 25 · 2020: 17 · 2019: 20 · 2018: 16 · 2017: 20 · 2016: 6
FWCI
8.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
National High-tech Research and Development Program (2011AA 02A 111)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
miR-155, atherosclerosis, foam cell formation, TNF-α, NF-κB, anti-inflammatory microRNA, chronic inflammation, lipid accumulation, microRNA target regulation, atherosclerotic plaque
MeSH terms
Base Sequence, Binding Sites, Cell Line, DNA-Binding Proteins, Foam Cells, Gene Expression Regulation, Humans, Luciferases, Phosphoproteins, Transcription Factors, Transcription, Genetic, Tumor Necrosis Factor-alpha, Case-Control Studies, NF-kappa B, Genes, Reporter, Feedback, Physiological, MicroRNAs, Atherosclerosis, Protein Stability, HEK293 Cells, Plaque, Atherosclerotic, Primary Cell Culture

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