Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma

Koirala, Pratistha, Roth, Michael E., Gill, Jonathan, Piperdi, Sajida, Chinai, Jordan M., Geller, David S., Hoang, Bang H., Park, Amy +3 more·2016·Scientific Reports
DOI 10.1038/srep30093

Cited by (267)

Items 201–267 of 267

  1. Indoleamine 2,3-dioxygenase 1 promotes osteosarcoma progression by regulating tumor-derived exosomal miRNA hsa-miR-23a-3p
    Dan Yang, Yinxian Chen, Zhen Ning Tony He, Yichen Wang, Chenghui Ke, Yi Luo, Wang Sun, Qichao Ma, Mengjie Chen, Qing Yang et al. · 2023 · Frontiers in Pharmacology
  2. PD-L1 expression in immune cells is a favorable prognostic factor for nasopharyngeal carcinoma
    Hayriye Şahinli, Nalân Akyürek, Mukaddes Yılmaz, Olçay Kandemir, Ayşe Ocak Duran, Sezer Kulaçoğlu, Gökhan Uçar, Elif Acar, Ahmet Özet, Mahmut Gümüş et al. · 2020 · Indian Journal of Cancer
  3. Endogenous retrovirus envelope as a tumor-associated immunotherapeutic target in murine osteosarcoma
    Mary Frances Wedekind, Katherine E. Miller, Chun‐Yu Chen, Pin-Yi Wang, Brian J. Hutzen, Mark A. Currier, Brooke A. Nartker, Ryan David Roberts, Louis Boon, Joe Conner et al. · 2021 · iScience
  4. The potentiality of immunotherapy for sarcomas: a summary of potential predictive biomarkers
    Jin Liang, Dedian Chen, Liyao Chen, Xueke She, Hushan Zhang, Yanbin Xiao · 2020 · Future Oncology
  5. TGFβ1: An Indicator for Tumor Immune Microenvironment of Colon Cancer From a Comprehensive Analysis of TCGA
    Jinyan Wang, Jinqiu Wang, Quan Gu, Yan T. Yang, Yajun Ma, Quan’an Zhang · 2021 · Frontiers in Genetics
  6. Oral TGF-βR1 inhibitor Vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity
    Sung Hee Choi, Jay Myers, Suzanne L. Tomchuck, Melissa Bonner, Saada K. Eid, Daniel Kingsley, Kristen A. VanHeyst, Seong‐Jin Kim, Byung‐Gyu Kim, Alex Yee-Chen Huang · 2023 · Research Square
  7. Targeting the osteosarcoma immune microenvironment for improved immunotherapy and translational applications
    Jinlin Cai, Shijie Qiu, Biao Sun, Jianbin Ge, Zhe Yu, Chao Wang · 2025 · Discover Oncology
  8. Targeted immune activation in pediatric solid tumors: opportunities to complement local control approaches
    Emily P. Vonderhaar, Michael B. Dwinell, Brian T. Craig · 2023 · Frontiers in Immunology
  9. Cytokine screening identifies TNF to potentially enhance immunogenicity of pediatric sarcomas
    Hendrik Gassmann, Melanie Thiede, Jennifer Weiß, Emilie Biele, Luisa Flohé, Helena Lachermaier, Carolin Prexler, Valentina E. Evdokimova, Laszlo George Radvanyi, Irfan Akhtar et al. · 2024 · Frontiers in Immunology
  10. Dendritic cell vaccine with Ag85A enhances anti‑colorectal carcinoma immunity
    Jingbo Zhai, Wei Gao, Leheng Zhao, Zhipeng Gao, Xuefeng Jiang, Changlong Lu · 2018 · Experimental and Therapeutic Medicine
  11. Large Scale Identification of Osteosarcoma Pathogenic Genes by Multiple Extreme Learning Machine
    Zhipeng Zhao, Jijun Shi, Guang Zhao, Yanjun Gao, Zhigang Jiang, Fusheng Yuan · 2021 · Frontiers in Cell and Developmental Biology
  12. In vitro assessment of PD-L1+ microvesicles in the cyst fluid of non-syndromic odontogenic keratocysts
    Qi‐Wen Man, Wenqun Zhong, Yi‐Fang Zhao, Bing Liu, Yi Fang Zhao · 2019 · Journal of Molecular Histology
  13. Ambivalent Copper: Mechanistically Distinct Immune Effects Driving Innovation in Cancer Nanomedicine
    Devon Heroux, XuXin Sun, Zeynab Nosrati, Marcel B. Bally · 2026 · Pharmaceutics
  14. Breaking down the tumor immune infiltration within pediatric sarcomas
    Rachel Weil, David Mark Loeb · 2023 · Frontiers in Endocrinology
  15. Multimodal Diagnostic Approach for Osteosarcoma and Bone Callus Using Hyperspectral Imaging and Deep Learning
    Yan Li, Bingsen Zhao, Sirui Li, Xiaoqing Yang, Minmin Yu, Zhijun Li · 2025 · Journal of Biophotonics
  16. SETDB1 amplification in osteosarcomas: Insights from its role in healthy tissues and other cancer types
    Elodie Verdier, Nathalie Gaspar, Maria Eugénia Marques Da Costa, Antonin Marchais · 2025 · Oncotarget
  17. Unaltered NKG2D-CAR T cell function under hypoxia in osteosarcoma in vitro
    Laura Hidalgo, Patricia Garcia-Rodriguez, Isabel Cubillo, Marta Zubizarreta, Antonio Pérez-Martínez, Javier Garcı́a-Castro · 2026 · Cancer Immunology Immunotherapy
  18. A conceptual blueprint for “turning cold to hot” in Osteosarcoma: from TME stratification hypotheses to adaptive therapeutic prospects
    Bai Yang, Shu Liu, Bingcheng Liu, Tianwen Ye, Xiao Ma, Tengfei Song · 2026 · Cell Communication and Signaling
  19. The Updated Status and Future Direction of Immunotherapy Targeting B7-H1/PD-1 in Osteosarcoma
    Mengke Fan, Lili Qi, Qi Zhang, Ling Wang · 2021 · Cancer Management and Research
  20. Immunotherapy of Osteosarcoma
    Agnes L. Sorteberg, Linnea Ek, Ingrid Lilienthal, Nikolas Herold · 2023 · Springer eBooks
  21. Identification and prognostic evaluation of differentially expressed long noncoding RNAs associated with immune infiltration in osteosarcoma
    Bangmin Wang, Xin Wang, Xinhui Du, Shilei Gao, Bo Liang, Weitao Yao · 2024 · Heliyon
  22. Investigation of prognostic values of immune infiltration and LGMN expression in the microenvironment of osteosarcoma
    Hualiang Xu, Dawei Xu, Yinfeng Zheng, Huajun Wang, Aiguo Li, Xiaofei Zheng · 2024 · Discover Oncology
  23. Cancer Stem Cells and Osteosarcoma: Opportunities and Limitations
    Abul Arif, Marc F. Hansen, Cynthia B. Alander, David K. Monson, Nickolas Bernard Reimer, Hicham Drissi · 2019 · Techniques in Orthopaedics
  24. Immunotherapeutic strategies for sarcoma: current perspectives.
    Xueyao Li, Gangyang Wang, Zhengdong Cai, Wei Yan Sun · 2020 · Europe PMC (PubMed Central)
  25. Single-cell RNA-seq reveals identity and heterogeneity of malignant osteoblast cells and TME in osteosarcoma
    Yan Zhou, Yang Dong, Qingcheng Yang, Xiaobin Lv, Wentao Huang, Zhenhua Zhou, Yaling Wang, Zhichang Zhang, Ting Yuan, Xiaomin Ding et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  26. Screening and identification Hub genes associated with immune cell infiltration and critical biomarkers in osteosarcoma
    Xin Song, Sihao Chen, Junning Cheng, Haiyu Li, Rui‐Xin Wu, Min Yan, Min Wang, Jie Li, Aishun Jin, Wang Wang · 2025 · Molecular and Cellular Probes
  27. Immunotherapy of Osteosarcoma
    Agnes L. Sorteberg, Linnea Ek, Ingrid Lilienthal, Nikolas Herold · 2025 · Springer eBooks
  28. Osteoidbildende Knochentumoren
    Albert Roessner, Victor Schoeder, Maria Anna Smolle, Johannes Haybäck · 2020 · Der Pathologe
  29. Immunotherapy in sarcoma
    Hanna Koseła-Paterczyk · 2020 · Nowotwory Journal of Oncology
  30. The immune environment of bone sarcomas
    Iseulys Richert, Aurélie Dutour · 2021 · Elsevier eBooks
  31. Identification of Two Novel Immune Subtypes Characterized by Distinct Prognosis and Tumor Microenvironment in Osteosarcoma
    Shunhan Yao, Meiling Deng, Xiaojing Du, Qingfeng Chen, Rongzhi Huang · 2022 · Journal of Immunology Research
  32. Investigating the Immune Microenvironment in Osteosarcomas
    Jung-Hyun Nam · 2017 · TSpace (University of Toronto)
  33. Immunomodulation with Radiation
    Jonathan E. Schoenhals, Taylor R. Cushman, Alexandra P. Cadena, Sandra Demaria, James William Welsh · 2018
  34. Prognostic and Clinicopathological Significance of Programmed Death-Ligand 1 in Osteosarcoma: a Meta-Analysis
    Xiaobin Gu · 2019 · Clinical surgery research communications
  35. Monitoring the Systemic Immune System to Understand and Improve the Efficacy of Immunotherapy for Metastatic Osteosarcoma
    Justin Markel · 2020
  36. Faculty Opinions recommendation of Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group.
    Nathalie Gaspar · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  37. Current Perspectives on Cancer Immunotherapy in Bone
    Katie L. Owen, Natasha K. Brockwell, Belinda S. Parker · 2019 · Elsevier eBooks
  38. Faculty Opinions recommendation of Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapy.
    Nathalie Gaspar · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  39. Wnt Signaling Pathway Related Gene CTNNBIP1 Act as A potential Prognostic Biomarker and A Comprehensive Prognostic Analysis in Osteosarcoma
    Jian Wen, Lijia WAN, Xieping Dong · 2022 · Research Square
  40. Radiation Therapy in Osteosarcoma
    Salvador Martín, Julieth Vivian Sarmiento Palma, Felipe Ángel Calvo · 2023 · Springer eBooks
  41. Data from Circulating Exosomal PD-L1 at Initial Diagnosis Predicts Outcome and Survival of Patients with Osteosarcoma
    Jun Wang, Wei Guo, Xiaofang Wang, Xiaodong Tang, Xin Sun, Tingting Ren · 2023
  42. The prognostic value of ubiquitin/ubiquitin-like-related genes along with immune cell infiltration and clinicopathological features in osteosarcoma
    Jian Wen, Lijia Wan, Wen‐Ming Chen, Xieping Dong · 2024 · Journal of Orthopaedic Surgery and Research
  43. PD-1 interactome in osteosarcoma: identification of a novel PD-1/AXL interaction conserved between humans and dogs
    Katarzyna Dziubek, Jakub Faktor, Kiran Bharat Lokhande, Ashish Shrivastava, Ines Papak, Elżbieta Chruściel, Magdalena Pilch, Theodore Hupp, Natalia Maria Marek-Trzonkowska, Ashutosh Singh et al. · 2024 · Cell Communication and Signaling
  44. A prognostic framework integrating endoplasmic reticulum stress dynamics reveals clinical stratification and differential prognostic attributes in osteosarcoma patients
    Yanjun Wang, Sina Ahmadi, Mingchao Ding, Yinggang Che, Changlong Song, Sijia Na, Weiqi Wang · 2025 · Frontiers in Medicine
  45. Functional biomaterials meet osteosarcoma treatment
    Ye Feng, Hai Huang, Dongdong Zhang, Zhaoyu Li, Feng Peng, Huihui Du, Xuanchen Liu, Lan Chen, Haobo Pan, Ning Wang et al. · 2026 · Smart Materials in Medicine
  46. Various Expression and Clinical Significance of Checkpoint Molecules in Advanced Osteosarcoma: Possibilities for Novel Immunotherapy
    Lu Xie, Chenglong Chen, Xin Liang, Jie Xu, Xin Sun, Kunkun Sun, Rongli Yang, Xiaodong Tang, Wei Guo · 2021 · Research Square
  47. Additional file 2 of The prognostic value of ubiquitin/ubiquitin-like-related genes along with immune cell infiltration and clinicopathological features in osteosarcoma
    Wen, Jian, Wan, Lijia, Chen, Wenming, Xieping Dong · 2024 · Figshare
  48. Additional file 3 of The prognostic value of ubiquitin/ubiquitin-like-related genes along with immune cell infiltration and clinicopathological features in osteosarcoma
    Wen, Jian, Wan, Lijia, Chen, Wenming, Xieping Dong · 2024 · Figshare
  49. Additional file 1 of Reprogramming tumor microenvironment via dual targeting co-delivery of regorafenib and alpha-difluoromethylornithine in osteosarcoma
    Wang, Hongsheng, Xinmeng Jin, Gao, Yinghua, He, Xin, Xu, Yiming, Mu, Haoran, Jiang, Yafei, Wang, Zhuoying, Yu, Chen, Zhang, Tao et al. · 2024 · Figshare
  50. Additional file 4 of The prognostic value of ubiquitin/ubiquitin-like-related genes along with immune cell infiltration and clinicopathological features in osteosarcoma
    Wen, Jian, Wan, Lijia, Chen, Wenming, Xieping Dong · 2024 · Figshare
  51. Additional file 1 of The prognostic value of ubiquitin/ubiquitin-like-related genes along with immune cell infiltration and clinicopathological features in osteosarcoma
    Wen, Jian, Wan, Lijia, Chen, Wenming, Xieping Dong · 2024 · Figshare
  52. Tumor Microenvironment: Current Understanding and Therapeutic Implications in Adult and Pediatric Cancers
    Satyendra Batra, Prashant Prabhakar, Debabrata Mohapatra, Noreen Grace George, Neha Goel, Bhavika Rishi, Aroonima Misra, Amitabh Singh · 2025 · Onco
  53. Prognostic Impact of CD206 + M2 ‐Like Macrophages in Canine Appendicular Osteosarcoma
    Gabriel Chamel, Sara Belluco, Laura E. Barrett, Franck Floch, David Sayag, Didier Lanore, Esther Piccirillo, Pauline Denoeux, Thomas Chavalle, Mathilde Lajoinie et al. · 2025 · Veterinary and Comparative Oncology
  54. Delayed Aggressive Local Recurrence of Chondroblastic Osteosarcoma 3 Years After an Excellent Pathological Response: A Case Report
    Abdul Hannan, Bilal Aslam, Natasha Elaine Hastings, Deepa Lachhman Das, Zahra Sania, Marium Mansoor, Fazeela Bibi, Khalil ELABDI, Samreen Najeeb, Kristen Batten et al. · 2026 · Clinical Case Reports
  55. Effets de la combinaison de la doxorubicine et de l’interférence avec la NTN1 sur la progression tumorale et l’infiltrat immunitaire de l’ostéosarcome
    M. Monchanin · 2017 · theses.fr (ABES)
  56. Rôle de la voie de signalisation Hippo dans le développement des ostéosarcomes
    Sarah Morice · 2019 · theses.fr (ABES)
  57. Implication de la voie de signalisation Wnt/β-caténine dans le développement tumoral primaire et métastatique des ostéosarcomes
    Geoffroy Danieau · 2019
  58. Rôle de l'hypoxie dans l'immunothérapie des ostéosarcomes pédiatriques ciblant le GD2
    Marina Pierrevelcin · 2021 · theses.fr (ABES)
  59. Utilisation de miRNAs thérapeutiques pour traiter les chondrosarcomes et les ostéosarcomes
    Clément Veys · 2021 · theses.fr (ABES)
  60. Evaluation of tumour-infiltrating immune cells and their prognostic value in feline appendicular osteosarcoma: a pilot study
    Arief Purwo Mihardi, Yumiko Kagawa, Yuko Nakano, Masanao Ichimata, Kei Harada, Eri Fukazawa, Fukiko Matsuyama, Tetsuya Kobayashi, Masaya Igase, Takuya Mizuno · 2026 · Journal of Comparative Pathology
  61. Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
    Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim Underwood, Zoë S. Walters, Matthew D. Blunt · 2026 · Pediatric Blood & Cancer
  62. Dedifferentiated Chondrosarcoma: Current Advances and Future Perspectives
    Rebecca Ibrahim, Julien Vibert, Tania Moussa, C. Duong-Ngo, Matthieu Faron, Benjamin Verret, Caterina Zanella, Rabih Mikhael, Elie I. Tabet, Antonin Lévy et al. · 2026 · Current Treatment Options in Oncology
  63. Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion
    Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim · 2026 · Advanced Materials
  64. Collagen targeting IL-12 combined with Doxorubicin enhances the anti-tumor effect against osteosarcoma
    Takumi Matsuo, Laurine Noblecourt, Pooja Kaur, Chuyi Wang, Po-Chuan Chiu, Koichi Sasaki, Takanatsu Hosokawa, Charanjit Singh, Adrian Lärkeryd, Tomonori Ueno et al. · 2026 · Journal of Controlled Release
  65. Single-cell landscape of lymphoid and myeloid heterogeneity across type-stratified craniofacial lesions in polyostotic fibrous dysplasia
    Huichuan Duan, Xia Liang, Decheng Wang, Jie Yuan, Fan Yang · 2026 · Frontiers in Immunology
  66. Biomarker-guided immunotherapy in osteosarcoma: from immune microenvironment profiling to patient stratification and combination strategies
    Qingqing Li · 2026 · Frontiers in Medicine
  67. Integrative bulk and single-cell transcriptomics identifies a HERC5-linked immune-attenuated risk program for pulmonary metastasis/relapse in osteosarcoma
    Zhangfu Li, Baicheng Yang, Shiqing Liu, Shengji Yu · 2026 · Translational Oncology