Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin

Mansuroglu, Zeyni, Benhelli-Mokrani, Houda, Marcato, Vasco, Sultan, Audrey, Violet, Marie, Chauderlier, Alban, Delattre, Lucie, Loyens, Anne +9 more·2016·Scientific Reports
DOI 10.1038/srep33047

Cited by (142)

Items 101–142 of 142

  1. Subcellular functions of tau mediate repair response and synaptic homeostasis in injury
    Riya Thomas, Die Zhang, Christopher A. Cronkite, Rintu Thomas, Sanjay Kumar Singh, Lawrence F. Bronk, Rodrigo Morales, Joseph G. Duman, David R. Grosshans · 2025 · Molecular Psychiatry
  2. Targeted downregulation of insulin signaling restricts human tau pathogenesis by reinstating the aberrant heterochromatin loss and mTOR/4EBP/S6K pathway in Drosophila
    Pragati, Surajit Sarkar · 2024 · Brain Research
  3. Controlled Tau Cleavage in Cells Reveals Abnormal Localizations of Tau Fragments
    Anne Fourest‐Lieuvin, Angélique Vinit, Béatrice Blot, Anthime Perrot, Éric Denarier, Frédéric Saudou, Isabelle Arnal · 2022 · Neuroscience
  4. Environmental Medical Epigenetics: A Review of Epigenetically Induced Medical Risks Generated From Exposures in our Air, Food, and Personal Products
    Rachel L. Miller · 2016 · Elsevier eBooks
  5. Pathogenic tau disrupts the cellular program that maintains neuronal identity
    Adrian Beckmann, Paulino Ramirez, Maria Gamez, William J. Ray, Bess E Frost · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Delaying Brain Aging or Decreasing Tau Levels as Strategies to Prevent Alzheimer’s Disease: In Memoriam of Mark A. Smith
    Jesús Ávila · 2024 · Journal of Alzheimer s Disease
  7. Loss of AT8 Nuclear Tau as a Marker of Neuronal Ageing and Alzheimer’s Disease Progression
    Francesca Bruno, Laura Gil, Valentina Sturiale, Carmen Guerrero, Ana Belén Rebolledo Poves, Desiree Brancato, Javier Morales, Salvatore Saccone, Concetta Federico · 2025 · Biomedicines
  8. A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice
    Zachary Mayeri, Georgia Woods, Anand Rane, A Kifle, Manish Chamoli, Shikha Shukla, Chaska C. Walton, Julie Kay Andersen · 2026 · GeroScience
  9. The Structure, Expression, and Non-Canonical Functions of Human rDNA: The Role of Non-Coding Regions
    A. A. Sadova, D. Yu. Panteleev, Galina Valerievna Pavlova · 2023 · Molecular Biology
  10. Irreversible modifications of chromatin and the nuclear lamina: A review inside the nuclear origin of Alzheimer’s disease
    Laura Gil, Gabriela Capdeville, Ildefonso Rodríguez‐Leyva, Sandra Aurora Niño, María Esther Jiménez-Capdeville · 2021 · Revista de Fomento Social
  11. Tau condensation on DNA mediates microtubule attachment suggesting a mitotic role for centromere-localized tau
    Celine Park, Jaehun Jung, Yuri Hong, Haeun Yoo, Keunsang Yang, Jaehyeon Shin, Minsik Kim, Chan Seok Lim, Ayoung Jeong, Seokyun Hong et al. · 2026 · Nature Communications
  12. Neuropharmacology in Flux: Molecular Modeling Tools for Understanding Protein Conformational Shifts in Alzheimer’s Disease and Related Disorders
    Gerald Henry Lushington, Frances E. S. Parker, Thomas H. W. Lushington, Nora M. Wallace · 2017 · Neuromethods
  13. Nuclear Tau as an Early Molecular Marker of Alzheimer’s Disease
    Francesca Bruno, Valentina Sturiale, Desiree Brancato, Laura Gil, Isabel M. Olazabal, Fernando Pinedo, Ana Belén Rebolledo Poves, Salvatore Saccone, Concetta Federico · 2023 · International Electronic Conference on Biomedicines (IECBM)
  14. Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope
    Lisa Diez, Renata Ponce-Lina, Cagla Kilic, Rithika Sankar, Frieda Balduin, Cong Wang, Pia Grundschöttel, Koki Sakurai, Bilge Askin, Chiara Bordier et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Human nuclear tau and aging
    Concetta Federico, Francesca Bruno, Valentina Sturiale, Agata Grazia D’Amico, Grazia Maugeri, Velia D’Agata, Laura Gil, Salvatore Saccone · 2021 · Elsevier eBooks
  16. Tau reduction impairs nephrocyte function in Drosophila
    Jiyoung Lee, Dayoung Kim, Sun Joo Cha, Jang-Won Lee, Eun Young Lee, Hyung-Jun Kim, Kiyoung Kim · 2025 · BMB Reports
  17. Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling
    Degisew Yinur Mengistu, Biniam Moges Eskeziyaw · 2026 · Brain and Behavior
  18. Regional and Cellular Distribution of Nuclear Phosphorylated Tau (AT100) in the Frontal Cortex and Cerebellum of Cetaceans
    Belén Alonso-Estanillo, Maicol Ochoa, Laura Gómez, Xabier Pin, Alfredo López, Fernando Vásquez · 2026 · Biology
  19. ZBP1 in Neuroinflammation and Neurodegeneration: Z-Nucleic-Acid Sensing, RHIM Signalling and Therapeutic Targeting
    Matei Șerban, Corneliu Toader, Răzvan-Adrian Covache-Busuioc · 2026 · International Journal of Molecular Sciences
  20. Human rDNA Structure, Expression, and Non-Canonical Functions: the Role of Non-Coding Regions
    A. A. Sadova, D. Yu. Panteleev, Galina Valerievna Pavlova · 2023 · Molecular Biology
  21. Neuronal Aging – Is it reversible?
    Jesús Ávila · 2023 · ANALES RANM
  22. Environmental medical epigenetics: A review of epigenetically induced medical risks generated from exposures in our air, food, and personal products
    Rachel L. Miller, Jessica Oh · 2021 · Elsevier eBooks
  23. Tau deficiency contributes to impaired bone formation via activating PPARγ signaling
    Meipeng Zhu, Shunze Hu, Jian Liu, Hui Chun Huang, Xuying Sun · 2025 · Cellular Signalling
  24. Urban air pollution reduces H3K9me2/me3 in hippocampal and olfactory neurons, correlating with memory and social deficits
    Nur Jury, Mario Sánchez-Rubio, Gino Nardocci, Constanza Mercado, Nicolas Peña-Baeza, Pablo Ruiz-Rudolph, Martin A. Montecino, Lorena Varela‐Nallar, Brigitte van Zundert · 2025 · The Science of The Total Environment
  25. Tau protein isoforms in neuropathological aging: Gerosuppressors, gerogenes or just travel companions
    Jesús Ávila, Félix Hernández, José Viña · 2025 · Geromedicine
  26. Spatial transcriptomics reveals an unexpected impact of tau and tau pathology on the expression of transthyretin
    Deborah L. Croteau, José Fernández Navarro, Thomas Comptdaer, Žaneta Andrusivová, Aleksandra Jurek, Eliette Bonnefoy, Luc Buée, Vilhelm A. Bohr, Joakim Lundeberg, Marie‐Christine Galas · 2025 · Frontiers in Aging Neuroscience
  27. Impact of Tau overexpression on DNA replication dynamics in centromeres of human neural progenitor cells
    Elisa Balzano, Shyam Twayana, Settapong T Kosiyatrakul, Glennis A. Logsdon, Bhushan L. Thakur, Evan E. Eichler, Bettina Bohl, Philipp Koch, Simone Sidoli, Anupama Kumari et al. · 2026 · iScience
  28. The loss of Tau in the adult brain triggers neuroplastic, epigenetic and behavioral deficits
    Joana Margarida Silva, Shibojyoti Lahiri, Daniela Monteiro‐Fernandes, Carina Soares‐Cunha, Victor Solis‐Mezarino, Moritz Carl Völker-Albert, Georgia Papadimitrou, Patricia A. Gomes, Carlos Marques, Bárbara Coimbra et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  29. Les nanotubes comme nouvelle voie de transfert et de propagation de la protéine Tau pathologique
    Meryem Tardivel · 2017 · theses.fr (ABES)
  30. Rôle de la dérégulation neuronale de la protéine kinase activée par l’AMP (AMPK) dans la pathologie tau, l’intégrité des synapses et le métabolisme énergétique : relevance pour la maladie d’Alzheimer
    Manon Domise · 2018 · theses.fr (ABES)
  31. Rôle de la neuroinflammation et du récepteur microglial TREM2 dans la progression de deux modèles de tauopathie
    Audrey Vautheny · 2019 · theses.fr (ABES)
  32. Prévention du phénomène de nucléation et de la propagation des tauopathies par immunothérapie passive utilisant un anticorps ciblant une région centrale de la protéine tau
    Marie Albert · 2018 · theses.fr (ABES)
  33. Étude de la composante neuroinflammatoire dans les DFT/SLA
    Julie Smeyers · 2020 · theses.fr (ABES)
  34. Caractérisation d'anticorps à domaine unique dirigés contre la protéine Tau
    Clément Danis · 2018 · theses.fr (ABES)
  35. The role of the serum response factor in the pathogenesis of Huntington's disease
    Ali Awada · 2021 · theses.fr (ABES)
  36. Interaction entre la protéine Tau et la protéine p54nrb : effet sur la maturation des miARN au sein des paraspeckles
    Marine Denéchaud · 2022 · theses.fr (ABES)
  37. Caractérisation et modulation du microbiote intestinal dans le contexte de la maladie d’Alzheimer : vers une nouvelle piste thérapeutique
    Caroline Ismeurt · 2021 · theses.fr (ABES)
  38. Astrocytes dysfunction in tauopathies
    Emma Augustin · 2023 · theses.fr (ABES)
  39. The Chromatin‐Modifying Protein RCOR2 / CoREST2 Safeguards Axon‐Dendrite Growth and Microtubule Stability in Brain Neurons
    Carlos Wilson, Victoria Rozés‐Salvador, José F. Drube, Andrés M. Cardozo Gizzi, Jerónimo Salguero, Ana Lis Moyano, Alfredo Cáceres · 2026 · Journal of Neurochemistry
  40. Nuclear dysfunction in aging and neurodegeneration
    Abbigael Aday, Jack Tiller, ADARSH MELUKOTE, Zachary C. Walton, Anna King, Luke Castillo, Rakez Kayed, Mauro Montalbano · 2026 · Alzheimer s & Dementia
  41. The truncated Tau fragment 315–441 produced by Caspase-2 translocates to the nucleus and alters the proteome of neuroblastoma cells
    Yadira Ivonne López-Aviña, Emmanuel Ríos‐Castro, Fanny Rodríguez‐Cruz, Graciela Mendoza-Franco, Bulmaro Cisneros Vega, Antony A. Boucard, Juan Pedro Luna‐Arias, Gustavo Basurto‐Islas, Francisco García‐Sierra · 2026 · European Journal of Cell Biology
  42. Metal accumulation as a potential modulator of tau phosphorylation in the common dolphin (Delphinus delphis): implications for marine environmental health
    Belén Alonso-Estanillo, Maicol Ochoa, Miguel Motas, Laura Gómez, Alfredo López, Adrian Wipf, Félix Zaragoza, Fernando Vásquez · 2026 · Frontiers in Marine Science