The significance of routine biochemical markers in patients with major depressive disorder
Open accessAbstract
The aim of our study is to examine the levels of routine biochemical markers in patients with major depressive disorder (MDD), and combine multiple biochemical parameters to assess the discriminative power for patients with MDD. We used the Hamilton Depression (HAMD) score to evaluate the severity of depressive symptoms in 228 patients with MDD. The phase of depression severity was between moderate and severe in MDD patients. There were significant differences between MDD patients and healthy controls in alanine transaminase (ALT), urea nitrogen (UN), lactate dehydrogenase (LDH), uric acid (UA), total protein (TP), total bile acid (TBA), creatinine (Cr), total bilirubin (Tbil), direct bilirubin (Dbil) and indirect bilirubin (Ibil), high density lipoprotein-cholesterol (HDL-C), fasting blood-glucose (FBG) and fructosamine (SF). Multivariate analysis showed that UN, FBG, HDL-C, SF, TP, Cr and Tbil remained independently association with MDD. Further, a logit equation was established to identify patients with MDD. The composite markers exhibited an area under the curve of 0.810 with cut-off values of 0.410. Our results suggest the associations between UN, FBG, HDL-C, TP, Cr, Tbil, SF and MDD, use of these routine biochemical markers in combination may contribute to improve the complete management for patients with MDD.
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Routine blood biochemical markers including HDL-C have been shown to be significant for identifying patients with MDD.
“On the other hand, a recent study has shown the significance of routine blood biochemical markers including high density lipoprotein-cholesterol (HDL-C) to identify patients with MDD (Peng et al., 2016).”
From Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study (2018) · cites this paper as Peng et al., 2016
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References 38 · Cited by 70
Research works printed but not linked: 3
- American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fourth edition. 4th edn. American Psychiatric Association: Washington, DC (2001).
- Hu A.. Major depressive disorder in hemodialysis pati ents in China. Asia Pac Psychiatry. 7, 78– 84 (2015). 24259452
- Rudich A., Kozlovsky N., Potashnik R. & Bashan N. Oxidanttress reduces insulin responsiveness in 3T3-L1 adipocytes. Am J Physiol. 272, E935– 940 (1997). 9176196
- Authors
- Peng, Y.-F., Xiang, Y., & Wei, Y.-S.
- Affiliations
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Corresponding author
- Wei, Ye-Sheng
- Venue
- Scientific Reports
- Published
- 2016-09-29
- Volume
- 6
- Issue
- 1
- Pages
- 34402-34402
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5041142
- OpenAlex
- W2524242235
- Cited by
- 70
- References
- 38
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 11 · 2023: 6 · 2022: 11 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 5
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, biochemical markers, serum biomarkers, urea nitrogen, fasting blood glucose, HDL cholesterol, fructosamine, total protein, creatinine, total bilirubin, uric acid, alanine aminotransferase, lactate dehydrogenase, depression severity, diagnostic biomarkers
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