Acidic pH Promotes Intervertebral Disc Degeneration: Acid-Sensing Ion Channel -3 as a Potential Therapeutic Target

Gilbert, Hamish T. J., Hodson, Nathan, Baird, Pauline, Richardson, Stephen M., Hoyland, Judith A.·2016·Scientific Reports
DOI 10.1038/srep37360

Cited by (141)

Items 101–141 of 141

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  5. Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats
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  6. Glis1 and oxaloacetate in nucleus pulposus stromal cell somatic reprogramming and survival
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  9. Development and characterization of antacid microcapsules to buffer the acidic intervertebral disc microenvironment
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  10. Bioactive Therapies for Degenerative Disc Disease: Microenvironmental Foundations of Disease
    Ashley Cardenas, Alikhan B Fidai, Chibuikem Anthony Ikwuegbuenyi, Anthony Robayo, Noah Willett, Ibrahim Hussain, Roger Härtl, Lawrence J. Bonassar · 2025 · World Neurosurgery
  11. [Research progress of hydrogel used for regeneration of nucleus pulposus in intervertebral disc degeneration].
    Kun Shi, Yong Huang, Leizhen Huang, Jingcheng Wang, Yuhan Wang, Ganjun Feng, Limin Liu, Yueming Song · 2020 · PubMed Central
  12. Lactylation driven by lactate metabolism in the disc accelerates intervertebral disc degeneration: A hypothesis
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  13. Association between anemia and lumbar disc degeneration in patients with low back pain: an observational retrospective study
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  14. Discharge Hemoglobin Impacts Functional Recovery After Lumbar Fusion
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  15. Targeting mitophagy and ferroptosis: A new direction for the treatment of intervertebral disc degeneration
    Yang Zhou, Yongliang Mei, Hong Wang, Pandeng Hao, Chao Song, Zongchao Liu, Jingwen Chen · 2025 · Tissue and Cell
  16. Influence of the Intervertebral Disc Microenvironment on Matrix Synthesis and Metabolism in Goat Nucleus Pulposus Cells
    Niamh Wilson, Tara Ní Néill, Jake Michael McDonnell, Emily E. McDonnell, Pieter A.J. Brama, Conor T. Buckley · 2026 · JOR Spine
  17. Lactate Metabolism in the Intervertebral Disc: Mechanistic Insights and Pathological Implications
    Ting Zhang, Peng Feng, Peter Geoffrey Alexander, J. Y. Lee, Gwendolyn Sowa, Nam Viet Vo · 2026 · Biomolecules
  18. Impact of the oxidative and enzymatic metals in degenerated intervertebral disc disease
    Mikołaj Dąbrowski, Anetta Zioła‐Frankowska, Janusz Adamek, Marcin Frankowski, Jacek Kaczmarczyk, Łukasz Kubaszewski · 2020 · Annals of Agricultural and Environmental Medicine
  19. Mitochondrial biogenesis microcarriers break membrane barriers for endogenous nucleus pulposus repair
    Xiaohu Li, Hongze Chang, Libin Pang, Ang Li, Juan Wang, Yi Yu, Honglei Xiao, Zhengwei Cai, Wenguo Cui, Xiaodong Liu · 2025 · Chemical Engineering Journal
  20. Controlled release of hypoxic exosomes from PLGA microspheres attenuates IVDD progression through activating PPAR-γ and suppressing oxidative stress-mediated NPCs senescence
    Weiqi Zhang, Han Yin, Chenchen Wang, Xiaowei Ma, Dazhuang Miao, Guimiao Li, Wei Chen, Zhiyong Hou, Xianda Gao, Yingze Zhang et al. · 2026 · Biomedicine & Pharmacotherapy
  21. Is Saline Injection a True Sham/Placebo Treatment in Randomized Controlled Trials? A Systematic Review
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  22. ASIC3 roles in mechanosensitive elongation of nucleus pulposus cells
    Jormay Lim, Shao-Shiang Huang, Mohammad Nikkhoo, Wei-Ting Tai, Ya-Cherng Chu, Andy Chien, Jaw‐Lin Wang · 2024 · Journal of Biomechanics
  23. Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges
    Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong · 2025 · Advanced NanoBiomed Research
  24. ASIC1a channel in Age-Related Diseases: Therapeutic Implications
    Renpeng Zhou, Hongyu Liang, Weirong Hu, Jie Ding, Shufang Li, Yong Chen, Yingjie Zhao, Chao Lü, Feihu Chen, Wei Ming Hu · 2022
  25. ENERGY SUPPLY AND DEMAND IN THE INTERVERTEBRAL DISC
    Liudmila Bardonova, Omar Sheikh, Irina Olegovna Malova, В. А. Сороковиков, Vadim A. Byvaltsev · 2018 · Coluna/Columna
  26. Lactate oxidative phosphorylation by annulus fibrosus cells: Evidence for lactate-dependent metabolic symbiosis in intervertebral discs
    Dong Wang, Robert A. Hartman, Chao Han, Chaoming Zhou, Brandon K. Couch, Matias Malkamaki, Vera Roginskava, Bennett Van Houten, Steven J. Mullett, Stacy Gelhaus Wendell et al. · 2020
  27. Additional file 1 of Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs
    Dong Wang, Robert A. Hartman, Chao Han, Chaoming Zhou, Brandon K. Couch, Matias Malkamaki, Vera Y. Roginskaya, Bennett Van Houten, Steven J. Mullett, Stacy Gelhaus Wendell et al. · 2021 · Figshare
  28. Spatiotemporal immunomodulation with programmable biomaterials to promote musculoskeletal tissue regeneration
    Chao Liang, Jiusi Guo, Wei Qiao, Sang Jin Lee · 2026 · Bioactive Materials
  29. Rôles et régulations des canaux ioniques ASIC1b dans la douleur
    Clément Verkest · 2019
  30. From Bench to Bedside: Translational Barriers in Mesenchymal Stem Cell Therapy for Intervertebral Disc Degeneration
    Lidija Gradišnik, Borut Prestor, Uroš Maver, Tomaž Velnar · 2026 · Bioengineering
  31. Gingerol-loaded hollow manganese dioxide nanoparticles attenuate intervertebral disc oxidative stress
    Xu Liu, Bolin Lu, Yunqi Zhou, Chengdong Zhang, Feng Shi, Gang Feng, Xuwei Luo, Dongqin Xiao · 2026 · RSC Advances
  32. Preconditioning Mesenchymal Stem Cells to Enhance Performance in the Degenerate Nucleus Pulposus
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  33. Defining the Human Nucleus Pulposus Microenvironment and Its Impact on Cell Matrix Synthesis and Metabolic Activity
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  34. Stress-response exhaustion in intervertebral disc degeneration
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  35. Lumbar Adjacent Segment Disease: A Modern Perspective and Review of the Literature
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  36. Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy
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  37. Organ‐on‐a‐Chip Technology: Advances in Modeling Inflammation, Neurovascularization and Nociception in Human Intervertebral Disc Degeneration
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  38. Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction
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  39. Computational screening of alginate biomaterials for intervertebral disc repair via agent-based simulation
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  40. Causal Effects of Plasma Metabolites on Intervertebral Disc Degeneration and Low Back Pain: A Mendelian Randomization Study
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  41. Injectable ECM-mimetic dynamic Schiff-base hydrogels deliver 5-aminosalicylic acid for immunomodulatory and alleviation of ferroptosis-associated injury of intervertebral disc degeneration
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