Serum vitamin D, intact parathyroid hormone, and Fetuin A concentrations were associated with geriatric sarcopenia and cardiac hypertrophy
Open accessAbstract
With aging, intact parathyroid hormone (iPTH) increases. It plays a crucial role in left ventricular hypertrophy (LVH). Also, 25-hydroxy vitamin D (Vit-D) and iPTH have been observed to be determinants of muscle wasting known as sarcopenia. Fetuin A (FetA), a systemic calcification inhibitor, involves in the development of diastolic heart failure. Hence, we hypothesized that the interplay among FetA, Vit-D and iPTH may contribute to sarcopenic LVH among the elders. We analyzed a database from the Tianliao Old People study with 541 elders (≥65 years) in a Taiwan’s suburban community. After excluding patients with renal function impairment, 120/449 (26.7%) patients were diagnosed with sarcopenia. Sarcopenic patients had lower serum Vit-D levels but higher FetA as well as iPTH. Notably, sarcopenic patients with LVH had significantly lower FetA and higher iPTH levels. In multivariate logistic regression analysis, only the increase in iPTH was independently associated with sarcopenic LVH (Odds ratio: 1.05; confidence interval: 1.03–1.08, p = 0.005). Using iPTH >52.3 ng/l as a cutoff point, the sensitivity and specificity was 66% and 84%, respectively. In conclusion, FetA, Vit-D, and iPTH levels were all associated with sarcopenia in this geriatric population. Among them, iPTH specifically indicates patients with sarcopenic LVH.
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Fetuin-A induces a pro-inflammatory milieu by polarizing M1 macrophages in WAT, generating ROS and reducing insulin sensitivity, which combined with other pro-inflammatory cytokines causes the development of sarcopenia.
“Fetuin-A, a systemic calcification inhibitor, induces a pro-inflammatory milieu by polarizing M1 macrophages in WAT, generating ROS and reducing insulin sensitivity, which combined with other pro-inflammatory cytokines causes the development of sarcopenia [122,123,124,125].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [123]
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References 32 · Cited by 27
- Authors
- Chang, W.-T., Wu, C.-H., Hsu, L.-W., Chen, P.-W., Yu, J.-R., Chang, C.-S., Tsai, W.-C., & Liu, P.-Y.
- Affiliations
- Chi Mei Medical Center (TW)
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
- China Medical University (TW)
- Corresponding author
- Liu, Ping-Yen
- Venue
- Scientific Reports
- Published
- 2017-01-23
- Volume
- 7
- Issue
- 1
- Pages
- 40996-40996
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5253676
- OpenAlex
- W2580914584
- Cited by
- 27
- References
- 32
- Citations by year
- 2025: 5 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 5 · 2019: 3 · 2018: 2 · 2017: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Health and Welfare
- Ministry of Science and Technology, Taiwan (MOST105-2314-B006-057-MY3, MOST103-2628-B006-002-MY4)
- National Cheng Kung University Hospital
- National Cheng Kung University
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Keywords
- sarcopenia, left ventricular hypertrophy, vitamin D, 25-hydroxyvitamin D, intact parathyroid hormone, fetuin-A, aging, older adults, heart failure with preserved ejection fraction, calcification inhibition, biomarkers
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Male, Parathyroid Hormone, Sensitivity and Specificity, Suburban Population, Taiwan, Vitamin D, Hypertrophy, Left Ventricular, Serum, Sarcopenia, alpha-2-HS-Glycoprotein
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