α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients

Dieriks, Birger Victor, Park, Thomas I-H., Fourie, Chantelle, Faull, Richard L. M., Dragunow, Mike, Curtis, Maurice A.·2017·Scientific Reports
DOI 10.1038/srep42984

Cited by (158)

Items 101–158 of 158

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  35. Tunneling Nanotubes (TNTs): Intratumoral Cell-to-Cell Communication and Mitochondria Trafficking Through Connections by Tunneling Nanotubes—Effects on Cell Metabolism and Response to Therapy
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  49. Mechanism of formation of tunneling nanotubes (TNTs) : focus on the role of actin organization and Eps8–I-BAR activity
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