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Cited by 23Neuroscience and Neuropharmacology ResearchStress Responses and CortisolMemory and Neural Mechanisms

A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system

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Lopes, M W, Leal, R B, Guarnieri, R, Schwarzbold, M L, Hoeller, A, Diaz, A P, Boos, G L, Lin, K +7 more·2016·Translational Psychiatry
DOI 10.1038/tp.2016.251PMC PMC5290343
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Abstract

Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly in the limbic circuits that modulates cognition, emotion and behavior. GC are the most commonly prescribed anti-inflammatory and immunosuppressant medication worldwide and pharmacological GC treatment has been paralleled by the high incidence of acute and chronic neuropsychiatric side effects, which reinforces the brain sensitivity for GC. Synapses can be bi-directionally modifiable via potentiation (long-term potentiation, LTP) or depotentiation (long-term depression, LTD) of synaptic transmission efficacy, and the phosphorylation state of Ser831 and Ser845 sites, in the GluA1 subunit of the glutamate AMPA receptors, are a critical event for these synaptic neuroplasticity events. Through a quasi-randomized controlled study, we show that a single high dexamethasone dose significantly reduces in a dose-dependent manner the levels of GluA1-Ser831 phosphorylation in the amygdala resected during surgery for temporal lobe epilepsy. This is the first report demonstrating GC effects on key markers of synaptic neuroplasticity in the human limbic system. The results contribute to understanding how GC affects the human brain under physiologic and pharmacologic conditions.

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Authors
Lopes, M. W., Leal, R. B., Guarnieri, R., Schwarzbold, M. L., Hoeller, A., Diaz, A. P., Boos, G. L., Lin, K., Linhares, M. N., Nunes, J. C., Quevedo, J., Bortolotto, Z. A., Markowitsch, H. J., Lightman, S. L., & Walz, R.
Affiliations
  • Universidade Federal de Santa Catarina (BR)
  • Governador Celso Ramos Hospital (BR)
  • The University of Texas Health Science Center at Houston (US)
  • University of Bristol (GB)
  • Bielefeld University (DE)
Corresponding author
Walz, R
ORCID
Venue
Translational Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2016-12-13
Volume
6
Issue
12
Pages
e986-e986
ISSN
2158-3188 (ISSN-L)
DOI
10.1038/tp.2016.251
PMC
PMC5290343
OpenAlex
W2561744811
Cited by
23
References
4
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 2 · 2018: 1 · 2017: 6
FWCI
1.31
Type
journal article
Language
en
Open access
Licence
Locations
  • Translational Psychiatry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Explore Bristol Research (submittedVersion, cc-by)
  • PUB – Publications at Bielefeld University (Bielefeld University) (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion, cc-by)
Funders
  • Wellcome Trust
  • University of Texas Health Science Center at Houston
  • McGovern Medical School
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (2013‐0, 56802/2010)
  • Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (56802/2010)
  • Universidade Federal de Santa Catarina
  • Universidade do Extremo Sul Catarinense
  • Instituto Mente e Cérebro - Neurociência
  • Medical Research Council
  • Biotechnology and Biological Sciences Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dexamethasone, glucocorticoids, AMPA receptors, GluR1, amygdala, limbic system, synaptic plasticity, long-term potentiation, long-term depression, temporal lobe epilepsy, dose-dependent effects
MeSH terms
Adult, Amygdala, Anti-Inflammatory Agents, Dexamethasone, Epilepsy, Temporal Lobe, Female, Hippocampus, Humans, Limbic System, Male, Neuronal Plasticity, Phosphorylation, Temporal Lobe, Signal Transduction, Receptors, AMPA

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