CHAPTER 3. Designing Multi-component Biodegradable/Biocompatible Amphiphilic Polymer Co-networks for Biomedical Applications
Abstract
This chapter presents novel, multi-component amphiphilic polymer co-networks (APCNs), which, in addition to the hydrophilic, typically poly(ethylene glycol) or poly[(2-dimethylamino)ethyl methacrylate], and hydrophobic, typically poly(e-caprolactone), polymeric components, a hydrophilic polysaccharide is also incorporated. These polysaccharides are agarose and dextran. The biocompatibility and biodegradability of the APCNs are investigated, as well as their drug loading capacity and release behaviour. The results indicate that the present APCNs represent excellent choices as materials for biomedical applications. Furthermore, this chapter compares the properties of common polymeric hydrogels with those of amphiphilic polymer co-networks, and provides our vision regarding the potential of degradable APCNs in biomedical applications.
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Grafting techniques and copolymerization with other natural or synthetic molecules can open novel facets in pH-responsive drug delivery.
“In addition, grafting techniques and copolymerization with other natural or synthetic molecules can open novel facets in the fields of pH responsive drug delivery (Bera et al., 2015; Chandel et al., 2016; Singh Chandel and Jewrajka, 2020).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Singh Chandel and Jewrajka, 2020
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pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery.
Vegad, U., Patel, M., Khunt, D., Zupančič, O., Chauhan, S., & Paudel, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1270364 · Cited by 85 · see citing works
- Authors
- Singh Chandel, A. K., & Jewrajka, S. K.
- ORCID
- Jewrajka, Suresh K.
- Venue
- Polymer Chemistry Series
- Publisher
- Royal Society of Chemistry
- Published
- 2020
- Pages
- 47-76
- ISSN
- 2044-0790 (ISSN-L)
- 2044-0804
- OpenAlex
- W3017720861
- Cited by
- 9
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2020: 1
- FWCI
- 1.97
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- RSC polymer chemistry series (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- biodegradable polymers, biocompatible polymers, polyethylene glycol, PDMAEMA, polycaprolactone, agarose, dextran, drug loading, controlled drug release, hydrogels, biomedical materials
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