The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Current progress in the asymmetric aldol addition reaction
Abstract
Control of stereochemistry during aldol addition reactions has attracted considerable interest over the years as the aldol reaction is one of the most fundamental tools for the construction of new carbon-carbon bonds. Several strategies have been implemented whereby eventually any single possible stereoisomeric aldol product can be accessed by choosing the appropriate procedure. With earlier methods, stoichiometric quantities of chiral reagents were required for efficient asymmetric induction, with the auxiliary most often attached covalently to the substrate carbonyl. Lewis acid catalyzed addition reactions of silyl enolates to aldehydes (Mukaiyama reaction) later opened the way for catalytic asymmetric induction. In the last few years, both chiral metal complexes and small chiral organic molecules have been found to catalyse the direct aldol addition of unmodified ketones to aldehydes with relatively high chemical and stereochemical efficiency. These techniques along with the more recent developments in the area are discussed in this tutorial review.
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Cites
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In the Golden Age of Organocatalysis
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Supramolecular Chirality in Self-Assembled Systems
Liu, M., Zhang, L., & Wang, T. (2015) · Chemical Reviews · doi:10.1021/cr500671p · Cited by 2,250
The Cross‐Dehydrogenative Coupling of CH Bonds: A Versatile Strategy for CC Bond Formations
Girard, S. A., Knauber, T., & Li, C. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201304268 · Cited by 1,861
When Organocatalysis Meets Transition‐Metal Catalysis
Zhong, C., & Shi, X. (2010) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201000004 · Cited by 607
Transition metal-catalyzed ketone-directed or mediated C–H functionalization
Huang, Z., Lim, H. N., Mo, F., Young, M. C., & Dong, G. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00272a · Cited by 584
Metadata
- Authors
- Palomo, C., Oiarbide, M., & García, J. M.
- Venue
- Chem. Soc. Rev.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2004
- Volume
- 33
- Issue
- 2
- Pages
- 65-75
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2140288236
- Cited by
- 465
- References
- 19
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
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