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New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.Electronic supplementary information (ESI) available: Mosher results for compound 3. See http://www.rsc.org/suppdata/ob/b2/b210039h/
Abstract
Chemical investigation of the two soft corals Nephthea sp. and Sarcophyton cherbonnieri, collected from the Fiji Islands and the Great Barrier Reef, respectively, led to the isolation of three new furano-cembranoids (1-3), two seco-cembranoid acetates (5, 6), along with the known compounds sarcoglaucol (4) and decaryiol (7). The structures of the new compounds were elucidated by employing spectroscopic techniques (NMR, MS, UV, IR and CD). Seco-cembranoids are extremely rare structures. Compounds 1, 3, and 7 were found to be cytotoxic towards several tumor cell lines (GI50 values ranged from 0.15 to 8.6 micrograms mL-1). Compound 7 arrests the cell cycle in the G2/M phase.
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“In vitro cytotoxicity testing showed that furano-cembranoids and decaryiol isolated from Nephthea spp. and Sarcophyton cherbonnieri are effective against several tumor cell lines (gastric epithelial, breast and liver) (with GI50 values ranging from 0.15 to 8.6 µg mL−1) via arrests the cell cycle in the G2/M phase [154].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [154]
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Metadata
- Authors
- Gross, H., Kehraus, S., Nett, M., König, G. M., Beil, W., & Wright, A. D.
- Affiliations
- University of Bonn (DE)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- König, Gabriele M.
- Venue
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2003-02-24
- Volume
- 1
- Issue
- 6
- Pages
- 944-949
- ISSN
- 1477-0520 (ISSN-L)
- 1477-0539
- OpenAlex
- W1907978658
- Cited by
- 36
- References
- 17
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Organic & Biomolecular Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Rheinische Friedrich-Wilhelms-Universität Bonn
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Physical Sciences › Chemistry › Organic Chemistry › Bioactive Natural Diterpenoids Research
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Keywords
- cembranoids, diterpenoids, soft coral, Nephthea, cytotoxicity, cancer cell lines, G2/M cell cycle arrest, natural product isolation, structure elucidation
- MeSH terms
- Animals, Antineoplastic Agents, Chromatography, High Pressure Liquid, Circular Dichroism, Cytotoxins, Diterpenes, Drug Screening Assays, Antitumor, Fiji, Humans, Models, Molecular, Magnetic Resonance Spectroscopy, Molecular Structure, Crystallography, X-Ray, Anthozoa, Cell Line, Tumor
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