Cited by 36Marine Sponges and Natural ProductsBioactive Natural Diterpenoids ResearchMicrobial Natural Products and Biosynthesis

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.Electronic supplementary information (ESI) available: Mosher results for compound 3. See http://www.rsc.org/suppdata/ob/b2/b210039h/

Abstract

Chemical investigation of the two soft corals Nephthea sp. and Sarcophyton cherbonnieri, collected from the Fiji Islands and the Great Barrier Reef, respectively, led to the isolation of three new furano-cembranoids (1-3), two seco-cembranoid acetates (5, 6), along with the known compounds sarcoglaucol (4) and decaryiol (7). The structures of the new compounds were elucidated by employing spectroscopic techniques (NMR, MS, UV, IR and CD). Seco-cembranoids are extremely rare structures. Compounds 1, 3, and 7 were found to be cytotoxic towards several tumor cell lines (GI50 values ranged from 0.15 to 8.6 micrograms mL-1). Compound 7 arrests the cell cycle in the G2/M phase.

Overview

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Crossref · 10.1039/b210039h

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17 of 17 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Gross, H., Kehraus, S., Nett, M., König, G. M., Beil, W., & Wright, A. D.
Affiliations
  • University of Bonn (DE)
  • Medizinische Hochschule Hannover (DE)
Corresponding author
König, Gabriele M.
Venue
Organic & Biomolecular Chemistry
Published
2003-02-24
Volume
1
Issue
6
Pages
944-949
ISSN
  • 1477-0520 (ISSN-L)
  • 1477-0539
OpenAlex
W1907978658
Cited by
36
References
17
Citations by year
2024: 2 · 2023: 2 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 4
FWCI
1.63
Type
journal article
Language
en
Open access
closed
Locations
  • Organic & Biomolecular Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Rheinische Friedrich-Wilhelms-Universität Bonn
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Physical Sciences › Chemistry › Organic Chemistry › Bioactive Natural Diterpenoids Research
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Keywords
cembranoids, diterpenoids, soft coral, Nephthea, cytotoxicity, cancer cell lines, G2/M cell cycle arrest, natural product isolation, structure elucidation
MeSH terms
Animals, Antineoplastic Agents, Chromatography, High Pressure Liquid, Circular Dichroism, Cytotoxins, Diterpenes, Drug Screening Assays, Antitumor, Fiji, Humans, Models, Molecular, Magnetic Resonance Spectroscopy, Molecular Structure, Crystallography, X-Ray, Anthozoa, Cell Line, Tumor

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