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Rapid and effective labeling of brain tissue using TAT-conjugated CdS∶Mn/ZnS quantum dots
Abstract
TAT (a cell penetrating peptide)-conjugated CdSratioMn/ZnS quantum dots (Qdots), intra-arterially delivered to a rat brain, rapidly (within a few minutes) labeled the brain tissue without manipulating the blood-brain-barrier (BBB). Qdot loading was sufficiently high that it allowed a gross fluorescent visualization of the whole rat brain using a low power hand-held UV lamp. Histological data clearly showed that TAT-conjugated Qdots migrated beyond the endothelial cell line and reached the brain parenchyma. Qdots without TAT did not label the brain tissue confirming the fact that TAT peptide was necessary to overcome the BBB. The present study clearly demonstrated the possibility of delivering a large amount of Qdot-based imaging agents to the brain tissue.
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Cited by
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Lim, S. Y., Shen, W., & Gao, Z. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00269e · Cited by 4,976
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Bera, D., Qian, L., Tseng, T.-K., & Holloway, P. H. (2010) · Materials · doi:10.3390/ma3042260 · Cited by 1,365
Self-citationSharma, P., Brown, S., Walter, G., Santra, S., & Moudgil, B. (2006) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2006.05.026 · Cited by 755
Self-citationDoped quantum dots for chemo/biosensing and bioimaging
Wu, P., & Yan, X.-P. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60017c · Cited by 667
Recent advances in the use of cell-penetrating peptides for medical and biological applications☆
Fonseca, S. B., Pereira, M. P., & Kelley, S. O. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.06.001 · Cited by 553
Metadata
- Authors
- Santra, S., Yang, H., Stanley, J. T., Holloway, P. H., Moudgil, B. M., Walter, G., & Mericle, R. A.
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2005
- Issue
- 25
- Pages
- 3144
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2022052082
- Cited by
- 215
- References
- 0
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Santra, S., Yang, H., Stanley, J. T., Holloway, P. H., Moudgil, B. M., Walter, G., & Mericle, R. A. (2005). Rapid and effective labeling of brain tissue using TAT-conjugated CdS∶Mn/ZnS quantum dots. Chemical Communications. https://doi.org/10.1039/b503234b
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