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Miniaturized continuous flow reaction vessels: influence on chemical reactions
Abstract
This review offers an overview of the relatively young research area of continuous flow lab-on-a-chip for synthetic applications. A short introduction on the basic aspects of lab-on-a-chip is given in the first part. Subsequently, the effects of downscaling reaction vessels as well as the advantages of the continuous flow microfluidic approach over conventional chemical laboratory batch methodologies are illustrated by a number of examples of organic reactions carried out in microfluidic devices. The last part deals with a key issue of the lab-on-a-chip approach, viz. the integration of the microreactor with the analytical instrumentation to achieve high-throughput reaction monitoring.
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Cites
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
Cited by
Control and detection of chemical reactions in microfluidic systems
deMello, A. J. (2006) · Nature · doi:10.1038/nature05062 · Cited by 1,495
The past, present and potential for microfluidic reactor technology in chemical synthesis
Elvira, K. S., i Solvas, X. C., Wootton, R. C. R., & deMello, A. J. (2013) · Nature Chemistry · doi:10.1038/nchem.1753 · Cited by 1,203
Flash chemistry: flow chemistry that cannot be done in batch
Yoshida, J.-I., Takahashi, Y., & Nagaki, A. (2013) · Chem. Commun. · doi:10.1039/c3cc44709j · Cited by 450
Girod, M., Moyano, E., Campbell, D. I., & Cooks, R. G. (2011) · Chem. Sci. · doi:10.1039/c0sc00416b · Cited by 419
Microfluidics: Applications for analytical purposes in chemistry and biochemistry
Ohno, K., Tachikawa, K., & Manz, A. (2008) · ELECTROPHORESIS · doi:10.1002/elps.200800121 · Cited by 398
Metadata
- Authors
- Brivio, M., Verboom, W., & Reinhoudt, D. N.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2006
- Volume
- 6
- Issue
- 3
- Pages
- 329
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2112473180
- Cited by
- 249
- References
- 1
- FWCI
- 14.14
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
