The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Direct sp3C–H bond activation adjacent to nitrogen in heterocycles
Abstract
Activation of sp(3) C-H bonds adjacent to nitrogen in heterocycles is an attractive transformation that is emerging as a practical method in organic synthesis. This tutorial review aims to summarize the key examples of direct functionalization of nitrogen-containing heterocycles via metal-mediated and metal-catalyzed processes, which is meant to serve as a foundation for future investigations into this rapidly developing area of research. The review covers functionalization of N-heterocycles via alpha-lithiation with alkyllithium/diamine complexes, alpha-amino radical formation, metal-catalyzed direct C-H activation, C-H oxidations and oxidative couplings, and metal-catalyzed carbene insertions.
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Comprehensive organic synthesis
Knochel, P., & Molander, G. A. (2014) · Elsevier eBooks · Cited by 6,231
Aerobic Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Sodium Cyanide
Murahashi, S.-I., Komiya, N., Terai, H., & Nakae, T. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0390303 · Cited by 474
Chatani, N., Asaumi, T., Yorimitsu, S., Ikeda, T., Kakiuchi, F., & Murai, S. (2001) · Journal of the American Chemical Society · doi:10.1021/ja011540e · Cited by 347
Beak, P., Kerrick, S. T., Wu, S., & Chu, J. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00087a008 · Cited by 324
Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine
Campos, K. R., Klapars, A., Waldman, J. H., Dormer, P. G., & Chen, C.-Y. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0605265 · Cited by 282
Self-citationA Readily-Accessible (+)-Sparteine Surrogate
Dearden, M. J., Firkin, C. R., Hermet, J.-P. R., & O'Brien, P. (2002) · Journal of the American Chemical Society · doi:10.1021/ja027774v · Cited by 242
Chatani, N., Asaumi, T., Ikeda, T., Yorimitsu, S., Ishii, Y., Kakiuchi, F., & Murai, S. (2000) · Journal of the American Chemical Society · doi:10.1021/ja002561w · Cited by 199
Bailey, W. F., Beak, P. A., Kerrick, S. T., et al. (2002) · Journal of the American Chemical Society · doi:10.1021/ja012169y · Cited by 107
Alkaloid total synthesis by intramolecular imino Diels-Alder cycloadditions
Weinreb, S. M. (1985) · Accounts of Chemical Research · doi:10.1021/ar00109a004 · Cited by 101
Enantioselective Synthesis of d -threo-Methylphenidate
Axten, J. M., Ivy, R., Krim, L., & Winkler, J. D. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991466o · Cited by 93
Cited by
Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization
Arockiam, P. B., Bruneau, C., & Dixneuf, P. H. (2012) · Chemical Reviews · doi:10.1021/cr300153j · Cited by 2,743
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
Cernak, T., Dykstra, K. D., Tyagarajan, S., Vachal, P., & Krska, S. W. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00628g · Cited by 1,743
Organocatalysis in Inert C–H Bond Functionalization
Qin, Y., Zhu, L., & Luo, S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00657 · Cited by 785
Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides
Jain, P., Verma, P., Xia, G., & Yu, J.-Q. (2017) · Nature Chemistry · doi:10.1038/nchem.2619 · Cited by 336
Practical Alkoxythiocarbonyl Auxiliaries for Iridium(I)‐Catalyzed C−H Alkylation of Azacycles
Tran, A. T., & Yu, J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201704755 · Cited by 105
Metadata
- Authors
- Campos, K. R.
- Venue
- Chem. Soc. Rev.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2007
- Volume
- 36
- Issue
- 7
- Pages
- 1069-1084
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2144577976
- Cited by
- 773
- References
- 11
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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