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Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa
Open accessAbstract
The toxicity of ethyl-, butyl-, octyl-, benzyl-, and allyl-substituted 1-alkyl-3-methylimidazolium, alkylpyridinium, N-alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium (choline derivatives) and alkyl-triethylammonium salts towards HeLa cells has been studied. The relative toxicities have been determined in the presence and absence of foetal bovine serum using an MTT assay after 24 and 48 h, and attempts to determine possible sources of the observed toxicity investigated using microscopy and by measuring the intracellular calcium concentration, presence of reactive oxygen species and mitochondrial membrane potential in cells exposed to 1-ethyl-3-methylimidazolium tetrafluoroborate.
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Citations
Cited by
Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine
Egorova, K. S., Gordeev, E. G., & Ananikov, V. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00562 · Cited by 1,649
Ionic liquids and catalysis: Recent progress from knowledge to applications
Olivier-Bourbigou, H., Magna, L., & Morvan, D. (2010) · Applied Catalysis A: General · doi:10.1016/j.apcata.2009.10.008 · Cited by 1,639
Egorova, K. S., & Ananikov, V. P. (2014) · ChemSusChem · doi:10.1002/cssc.201300459 · Cited by 441
Li, X., Ma, J., & Wang, J. (2015) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2015.06.018 · Cited by 105
Metadata
- Authors
- Wang, X., Ohlin, C. A., Lu, Q., Fei, Z., Hu, J., & Dyson, P. J.
- Venue
- Green Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2007
- Volume
- 9
- Issue
- 11
- Pages
- 1191
- ISSN
- 1463-9262 (ISSN-L)
- 1463-9270
- OpenAlex
- W2071039346
- Cited by
- 205
- References
- 0
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, X., Ohlin, C. A., Lu, Q., Fei, Z., Hu, J., & Dyson, P. J. (2007). Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa. Green Chemistry. https://doi.org/10.1039/b704503d
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