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Polymer microcapsules as mobile local pH-sensors

Kreft, Oliver, Javier, Almudena Muñoz, Sukhorukov, Gleb B., Parak, Wolfgang J.·2007·Journal of Materials Chemistry

Abstract

Polyelectrolyte microcapsules have been loaded with a pH-sensitive, high molecular weight SNARF-1-dextran conjugate. SNARF-1 exhibits a significant pH-dependent emission shift from green to red fluorescence under acidic and basic conditions, respectively. The unique spectral properties of the dye were maintained after the encapsulation. By investigating both human breast cancer cells and fibroblasts, we were able to follow the pH change of the local environment of SNARF-1-filled capsules during the transition from the alkaline cell medium to the acidic endosomal/lysosomal compartments. The incorporation of magnetite nanoparticles and an additional pH-insensitive fluorophore within the capsule shell resulted in a novel type of sensor system based on multifunctional polymer capsules.

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Metadata

Authors
Kreft, O., Javier, A. M., Sukhorukov, G. B., & Parak, W. J.
Venue
Journal of Materials Chemistry
Published
2007
Volume
17
Issue
42
Pages
4471
ISSN
  • 0959-9428 (ISSN-L)
  • 1364-5501
OpenAlex
W2069087929
Cited by
255
References
0
FWCI
16.06
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Polymer microcapsules as mobile local pH-sensors. https://app.cochat.ai/papers/10.1039/b705419j
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Kreft, O., Javier, A. M., Sukhorukov, G. B., & Parak, W. J. (2007). Polymer microcapsules as mobile local pH-sensors. Journal of Materials Chemistry. https://doi.org/10.1039/b705419j

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.