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Intelligent routes to the controlled synthesis of nanoparticles
Abstract
We describe an autonomous 'black-box' system for the controlled synthesis of fluorescent nanoparticles. The system uses a microfluidic reactor to carry out the synthesis and an in-line spectrometer to monitor the emission spectra of the emergent particles. The acquired data is fed into a control algorithm which reduces each spectrum to a scalar 'dissatisfaction coefficient' and then intelligently updates the reaction conditions in an effort to minimise this coefficient and so drive the system towards a desired goal. In the tests reported here, CdSe nanoparticles were prepared by separately injecting solutions of CdO and Se into the two inlets of a heated y-shaped microfluidic reactor. A noise-tolerant global search algorithm was then used to efficiently identify-without any human intervention-the injection rates and temperature that yielded the optimum intensity for a chosen emission wavelength.
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Cited by
The Hitchhiker’s Guide to Flow Chemistry
Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995
The past, present and potential for microfluidic reactor technology in chemical synthesis
Elvira, K. S., i Solvas, X. C., Wootton, R. C. R., & deMello, A. J. (2013) · Nature Chemistry · doi:10.1038/nchem.1753 · Cited by 1,203
Self-citationSchneider, G. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.232 · Cited by 910
Microfluidic Platform for Controlled Synthesis of Polymeric Nanoparticles
Karnik, R., Gu, F., Basto, P., Cannizzaro, C., Dean, L., Kyei-Manu, W., Langer, R., & Farokhzad, O. C. (2008) · Nano Letters · doi:10.1021/nl801736q · Cited by 887
Synthesis of micro and nanostructures in microfluidic systems
Marre, S., & Jensen, K. F. (2010) · Chemical Society Reviews · doi:10.1039/b821324k · Cited by 734
Metadata
- Authors
- Krishnadasan, S., Brown, R. J. C., deMello, A. J., & deMello, J. C.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2007
- Volume
- 7
- Issue
- 11
- Pages
- 1434
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2132402242
- Cited by
- 310
- References
- 0
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Krishnadasan, S., Brown, R. J. C., deMello, A. J., & deMello, J. C. (2007). Intelligent routes to the controlled synthesis of nanoparticles. Lab on a Chip. https://doi.org/10.1039/b711412e
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