The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Diversity-oriented synthesis; a spectrum of approaches and results
Abstract
Since our emerging area article, diversity-oriented synthesis (DOS), which aims to prepare efficiently collections of skeletally diverse small molecules, has developed in the synthetic approaches it employs. This article describes three general strategies, highlighting some successful examples. The utility of DOS, in the interrogation of chemical space and in the identification of novel biologically active lead compounds, is also discussed.
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Cites
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
How many drug targets are there?
Overington, J. P., Al-Lazikani, B., & Hopkins, A. L. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2199 · Cited by 3,505
Hopkins, A. L., & Groom, C. R. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd892 · Cited by 3,305
Diversity-oriented synthesis: Exploring the intersections between chemistry and biology
Tan, D. S. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0705-74 · Cited by 605
Cited by
Impact of Natural Products on Developing New Anti-Cancer Agents
Cragg, G. M., Grothaus, P. G., & Newman, D. J. (2009) · Chemical Reviews · doi:10.1021/cr900019j · Cited by 1,302
Galloway, W. R. J. D., Isidro-Llobet, A., & Spring, D. R. (2010) · Nature Communications · doi:10.1038/ncomms1081 · Cited by 891
Self-citationApplications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds
Sunderhaus, J. D., & Martin, S. F. (2009) · Chemistry – A European Journal · doi:10.1002/chem.200802140 · Cited by 745
Multicomponent reactions for the synthesis of pyrroles
Estévez, V., Villacampa, M., & Menéndez, J. C. (2010) · Chemical Society Reviews · doi:10.1039/b917644f · Cited by 744
In situ click chemistry: probing the binding landscapes of biological molecules
Mamidyala, S. K., & Finn, M. G. (2010) · Chemical Society Reviews · doi:10.1039/b901969n · Cited by 489
Metadata
- Authors
- Spandl, R. J., Bender, A., & Spring, D. R.
- Venue
- Organic & Biomolecular Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2008
- Volume
- 6
- Issue
- 7
- Pages
- 1149
- ISSN
- 1477-0520 (ISSN-L)
- 1477-0539
- OpenAlex
- W2143809707
- Cited by
- 281
- References
- 4
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spandl, R. J., Bender, A., & Spring, D. R. (2008). Diversity-oriented synthesis; a spectrum of approaches and results. Organic & Biomolecular Chemistry. https://doi.org/10.1039/b719372f
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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