The chemistry of Alzheimer’s disease
Abstract
The chemistry of Alzheimer's disease is largely centred on the amyloid beta-peptide, its formation, structure, and interactions with metals, membranes, proteins and other species. This critical review summarizes the current state of knowledge (252 references).
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These metal ions lead to formation of reactive oxygen species (ROS) and oxidative stress.
“as well as lead to formation of reactive oxygen species (ROS) and oxidative stress.3,26–31,33–36”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [30]
These metal ions have been shown to promote Aβ40 aggregation.
“Thus, these metal ions have been shown to promote Aβ40 aggregation,23–27,29–32”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [30]
This is in contrast with a large number of reports showing the aggregation-promoting effect of metal ions on the Aβ peptide.
“This is in contrast with a large number of reports showing the aggregation-promoting effect of metal ions on the Aβ peptide.23–27,29–32,37,38”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ<sub>42</sub>Peptide (2012) · cites this paper as [30]
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References 237 · Cited by 417
- Authors
- Rauk, A.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Rauk, Arvi
- ORCID
- Rauk, Arvi
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 38
- Issue
- 9
- Pages
- 2698
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2095360134
- Cited by
- 417
- References
- 237
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 14 · 2023: 22 · 2022: 24 · 2021: 15 · 2020: 23 · 2019: 24 · 2018: 35 · 2017: 13 · 2016: 35 · 2015: 40 · 2014: 31 · 2013: 36 · 2012: 36
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, amyloid-beta, amyloid fibril formation, metal-peptide interactions, membrane interactions, protein-protein interaction, peptide structure, neurodegeneration
- MeSH terms
- Alzheimer Disease, Animals, Copper, Free Radicals, Humans, Models, Molecular, Oxidation-Reduction, Protein Binding, Amyloid beta-Peptides, Mice, Protein Multimerization
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