The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reliable microfluidic on-chip incubation of droplets in delay-lines
Open accessAbstract
Together with droplet creation, fusion and sorting, the incubation of droplets is one of the most important and essential operations for droplet-based microfluidic assays. This manuscript concerns the development of delay-lines, which are necessary to allow incubation of reactions for precise time periods. We analyze the problems associated with creating delay-lines for incubation in the minute to hour time range, which arise from back-pressure and from the dispersion in the incubation time due to the unequal speeds with which droplets pass through the delay-line. We describe delay-line systems which resolve these problems and demonstrate their use to measure reaction kinetics over several minutes in droplets.
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Cites
Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents
Song, H., & Ismagilov, R. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0354566 · Cited by 693
Cited by
Single-cell analysis and sorting using droplet-based microfluidics
Mazutis, L., Gilbert, J., Ung, W. L., Weitz, D. A., Griffiths, A. D., & Heyman, J. A. (2013) · Nature Protocols · doi:10.1038/nprot.2013.046 · Cited by 1,355
Self-citationDroplet microfluidic technology for single-cell high-throughput screening
Brouzes, E., Medkova, M., Savenelli, N., Marran, D., Twardowski, M., Hutchison, J. B., Rothberg, J. M., Link, D. R., Perrimon, N., & Samuels, M. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903542106 · Cited by 1,069
Self-citationSurfactants in droplet-based microfluidics
Baret, J.-C. (2012) · Lab Chip · doi:10.1039/c1lc20582j · Cited by 649
Latest Developments in Micro Total Analysis Systems
Arora, A., Simone, G., Salieb-Beugelaar, G. B., Kim, J. T., & Manz, A. (2010) · Analytical Chemistry · doi:10.1021/ac100969k · Cited by 421
Moragues, T., Arguijo, D., Beneyton, T., Modavi, C., Simutis, K., Abate, A. R., Baret, J.-C., deMello, A. J., Densmore, D., & Griffiths, A. D. (2023) · Nature Reviews Methods Primers · doi:10.1038/s43586-023-00212-3 · Cited by 316
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Metadata
- Authors
- Frenz, L., Blank, K., Brouzes, E., & Griffiths, A. D.
- Venue
- Lab Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 9
- Issue
- 10
- Pages
- 1344-1348
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W1976147756
- Cited by
- 170
- References
- 1
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Frenz, L., Blank, K., Brouzes, E., & Griffiths, A. D. (2009). Reliable microfluidic on-chip incubation of droplets in delay-lines. Lab Chip. https://doi.org/10.1039/b816049j
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