The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structural insights into nonribosomal peptide enzymatic assembly lines
Open accessAbstract
Nonribosomal peptides have a variety of medicinal activities including activity as antibiotics, antitumor drugs, immunosuppressives, and toxins. Their biosynthesis on multimodular assembly lines as a series of covalently tethered thioesters, in turn covalently attached on pantetheinyl arms on carrier protein way stations, reflects similar chemical logic and protein machinery to fatty acid and polyketide biosynthesis. While structural information on excised or isolated catalytic adenylation (A), condensation (C), peptidyl carrier protein (PCP) and thioesterase (TE) domains had been gathered over the past decade, little was known about how the NRPS catalytic and carrier domains interact with each other both within and across elongation or termination modules. This Highlight reviews recent breakthrough achievements in both X-ray and NMR spectroscopic studies that illuminate the architecture of NRPS PCP domains, PCP-containing didomain-fragments and of a full termination module (C-A-PCP-TE).
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Quadri, L. E. N., Weinreb, P. H., Lei, M., Nakano, M. M., Zuber, P., & Walsh, C. T. (1998) · Biochemistry · doi:10.1021/bi9719861 · Cited by 693
Self-citationIn vitro characterization of IroB, a pathogen-associated C -glycosyltransferase
Fischbach, M. A., Lin, H., Liu, D. R., & Walsh, C. T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408463102 · Cited by 169
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Cited by
Natural Products Version 2.0: Connecting Genes to Molecules
Walsh, C. T., & Fischbach, M. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909118a · Cited by 468
Self-citationNonribosomal peptide synthetases: structures and dynamics
Strieker, M., Tanović, A., & Marahiel, M. A. (2010) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2010.01.009 · Cited by 441
Heard, S. C., & Winter, J. M. (2024) · Natural Product Reports · doi:10.1039/d3np00064h · Cited by 35
Metadata
- Authors
- Koglin, A., & Walsh, C. T.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 26
- Issue
- 8
- Pages
- 987
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2061278426
- Cited by
- 185
- References
- 2
- FWCI
- 13.45
- Type
- journal article
- Language
- en
- Open access
- green
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