Multi-component extracellular matrices based on peptide self-assembly
Open accessAbstract
Extracellular matrices (ECMs) are challenging design targets for materials synthesis because they serve multiple biological roles, and they are composed of multiple molecular constituents. In addition, their composition and activities are dynamic and variable between tissues, and they are difficult to study mechanistically in physiological contexts. Nevertheless, the design of synthetic ECMs is a central consideration in applications such as regenerative medicine and 3D cell culture. In order to produce synthetic matrices having both multi-component construction and high levels of compositional definition, strategies based on molecular self-assembly are receiving increasing interest. These approaches are described in this tutorial review and compared with the structures and processes in native ECMs that serve as their inspiration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Certain recombinant proteins and self-assembling peptides are immunogenic.
“Certain recombinant proteins and self-assembling peptides are immunogenic214–218.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [215]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 70 · Cited by 229
- Authors
- Collier, J. H., Rudra, J. S., Gasiorowski, J. Z., & Jung, J. P.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Collier, Joel H.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 39
- Issue
- 9
- Pages
- 3413
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- PMC
- PMC3387682
- OpenAlex
- W2065883990
- Cited by
- 229
- References
- 70
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 12 · 2022: 9 · 2021: 15 · 2020: 16 · 2019: 10 · 2018: 13 · 2017: 17 · 2016: 15 · 2015: 19 · 2014: 25 · 2013: 29 · 2012: 18
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Chemical Society Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R21EB007335, R01EB009701)
- Division of Chemistry
- Topics
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- extracellular matrix, peptide self-assembly, synthetic extracellular matrix, biomimetic materials, regenerative medicine, 3D cell culture, tissue engineering, biomaterial design
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Humans, Peptide Fragments
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
