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Novel biocompatible cholinium-based ionic liquids—toxicity and biodegradability
Abstract
The synthesis, characterisation and toxicological assessment of a new group of environmentally friendly ionic liquids are presented. Focussing on the toxic effect of the anion, the ionic liquids were designed by combining the benign cholinium cation, [NMe3(CH2CH2OH)]+, with a range of linear alkanoate anions ([CnH2n+1CO2]−, n = 1-9), as well as two structural isomers (n = 3 or 4). The toxicity of these ionic liquids was evaluated using filamentous fungi as model eukaryotic organisms. Surprisingly, most of the tested species showed active growth in media containing extremely high ionic liquid concentrations, up to molar ranges in some cases. The biodegradability of these ionic liquids was assessed, and new biotechnological applications for them are proposed, e.g. as solvents for biopolymers. This study leads to the better understanding of the anion influence on the ionic liquid toxicity, but its core is the recognition that conscious design of ionic liquids can be used to deliver truly biocompatible salts without adversely affecting one of the most striking of their properties—their outstanding solvent ability.
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Citations
Cites
Applications of ionic liquids in the chemical industry
Plechkova, N. V., & Seddon, K. R. (2008) · Chem. Soc. Rev. · doi:10.1039/b006677j · Cited by 5,686
Self-citation
Cited by
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Low melting mixtures in organic synthesis–an alternative to ionic liquids?
Ruß, C., & König, B. (2012) · Green Chemistry · doi:10.1039/c2gc36005e · Cited by 654
Assessing the toxicity and biodegradability of deep eutectic solvents
Wen, Q., Chen, J.-X., Tang, Y.-L., Wang, J., & Yang, Z. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.02.061 · Cited by 480
Green solvents for green technologies
Cvjetko Bubalo, M., Vidović, S., Radojčić Redovniković, I., & Jokić, S. (2015) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.4668 · Cited by 453
Liu, Q.-P., Hou, X.-D., Li, N., & Zong, M.-H. (2012) · Green Chem. · doi:10.1039/c2gc16128a · Cited by 441
Metadata
- Authors
- Petkovic, M., Ferguson, J. L., Gunaratne, H. Q. N., Ferreira, R., Leitão, M. C., Seddon, K. R., Rebelo, L. P. N., & Pereira, C. S.
- Venue
- Green Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 12
- Issue
- 4
- Pages
- 643
- ISSN
- 1463-9262 (ISSN-L)
- 1463-9270
- OpenAlex
- W2036573647
- Cited by
- 563
- References
- 1
- FWCI
- 10.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Petkovic, M., Ferguson, J. L., Gunaratne, H. Q. N., Ferreira, R., Leitão, M. C., Seddon, K. R., Rebelo, L. P. N., & Pereira, C. S. (2010). Novel biocompatible cholinium-based ionic liquids—toxicity and biodegradability. Green Chemistry. https://doi.org/10.1039/b922247b
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