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Desorption electrospray ionization and other ambient ionization methods: current progress and preview
Abstract
Mass spectrometry allows rapid chemical analysis of untreated samples in the ambient environment. This is a result of recent rapid progress in ambient ionization techniques. The most widely studied of these new methods, desorption electrospray ionization (DESI), uses fast-moving solvent droplets to extract analytes from surfaces and propel the resulting secondary microdroplets towards the mass analyzer. This review of DESI and other ambient methods centers on the accompanying chemical processes. Manipulation of the chemistry accompanying ambient ionization can be used to optimize chemical analysis, including molecular imaging. Solvent effects, geometry effects, electrochemical processes and mechanisms are covered. Extensions of the methodology to solution-phase analysis, to stand-off detection and to therapeutic drug analysis using miniature mass spectrometers are also treated.
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Cited by
Ambient Sampling/Ionization Mass Spectrometry: Applications and Current Trends
Harris, G. A., Galhena, A. S., & Fernández, F. M. (2011) · Analytical Chemistry · doi:10.1021/ac200918u · Cited by 527
Mass spectrometry imaging under ambient conditions
Wu, C., Dill, A. L., Eberlin, L. S., Cooks, R. G., & Ifa, D. R. (2013) · Mass Spectrometry Reviews · doi:10.1002/mas.21360 · Cited by 488
Self-citationMass Spectrometry: Recent Advances in Direct Open Air Surface Sampling/Ionization
Monge, M. E., Harris, G. A., Dwivedi, P., & Fernández, F. M. (2013) · Chemical Reviews · doi:10.1021/cr300309q · Cited by 476
Ambient mass spectrometry: bringing MS into the “real world”
Alberici, R. M., Simas, R. C., Sanvido, G. B., Romão, W., Lalli, P. M., Benassi, M., Cunha, I. B. S., & Eberlin, M. N. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3808-3 · Cited by 340
An update of MALDI-TOF mass spectrometry in lipid research
Fuchs, B., Süß, R., & Schiller, J. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.07.001 · Cited by 324
Metadata
- Authors
- Ifa, D. R., Wu, C., Ouyang, Z., & Cooks, R. G.
- Venue
- The Analyst
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 135
- Issue
- 4
- Pages
- 669
- ISSN
- 0003-2654 (ISSN-L)
- 1364-5528
- OpenAlex
- W2040677997
- Cited by
- 384
- References
- 0
- FWCI
- 22.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ifa, D. R., Wu, C., Ouyang, Z., & Cooks, R. G. (2010). Desorption electrospray ionization and other ambient ionization methods: current progress and preview. The Analyst. https://doi.org/10.1039/b925257f
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